RNR3/YIL066C Summary

RNR3 BASIC INFORMATION

Standard Name	RNR3 1
Systematic Name	YIL066C
Alias	DIN1 2 , RIR3
Feature Type	ORF, Verified
Description	One of two large regulatory subunits of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits (1, 3)
Name Description	RiboNucleotide Reductase

GO Annotations	All RNR3 GO evidence and references
	View Computational GO annotations for RNR3
Molecular Function
Manually curated	ribonucleoside-diphosphate reductase activity (IDA)
Biological Process
Manually curated	deoxyribonucleotide biosynthetic process (IDA)
Cellular Component
Manually curated	cytoplasm (IDA) ribonucleoside-diphosphate reductase complex (TAS)
High-throughput	mitochondrion (IDA)

Pathways	de novo biosynthesis of purine nucleotides de novo biosynthesis of pyrimidine deoxyribonucleotides superpathway of histidine, purine, and pyrimidine biosynthesis superpathway of purine biosynthesis and salvage pathways

Mutant Phenotype	All RNR3 Phenotype details and references
Classical genetics
null	viable
Large-scale survey
null	viable

Interactions	RNR3 All interactions details and references
	26 total interaction(s) for 23 unique genes/features.
Physical Interactions	Affinity Capture-MS: 13 Co-fractionation: 1 Two-hybrid: 2
Genetic Interactions	Dosage Rescue: 4 Phenotypic Enhancement: 3 Synthetic Growth Defect: 1 Synthetic Rescue: 2

Sequence Information

ChrIX:240705 to 238096 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 1994-12-10 | Sequence: 1994-12-10

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..2610	240705..238096	1994-12-10	1994-12-10

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000001328

RNR3 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for RNR3

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for RNR3]

1)	Elledge SJ and Davis RW (1990) Two genes differentially regulated in the cell cycle and by DNA-damaging agents encode alternative regulatory subunits of ribonucleotide reductase. Genes Dev 4(5):740-51
2)	Ruby SW and Szostak JW (1985) Specific Saccharomyces cerevisiae genes are expressed in response to DNA-damaging agents. Mol Cell Biol 5(1):75-84
3)	Yao R, et al. (2003) Subcellular localization of yeast ribonucleotide reductase regulated by the DNA replication and damage checkpoint pathways. Proc Natl Acad Sci U S A 100(11):6628-33

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