RNH201/YNL072W Summary Help

RNH201 BASIC INFORMATION

Standard Name RNH201
Systematic Name YNL072W
Alias RNH35 1
Feature Type ORF, Verified
Description Ribonuclease H2 catalytic subunit, removes RNA primers during Okazaki fragment synthesis; homolog of RNAse HI (the S. cerevisiae homolog of mammalian RNAse HII is RNH1); related to human AGS4 that causes Aicardi-Goutieres syndrome (1, 2, 3)
Name Description RNase H 1
Gene Product Alias Rnh2A
GO Annotations All RNH201 GO evidence and references
    View Computational GO annotations for RNH201
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All RNH201 Phenotype details and references
Classical genetics
null
Large-scale survey
null
Interactions RNH201 All interactions details and references
  View additional details at BioGRID
58 total interaction(s) for 43 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 3
  • Affinity Capture-RNA: 1
Genetic Interactions
  • Negative Genetic: 26
  • Phenotypic Suppression: 3
  • Positive Genetic: 11
  • Synthetic Growth Defect: 10
  • Synthetic Lethality: 4
Sequence Information
ChrXIV:490319 to 491242 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 2010-01-05 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..924 490319..491242 2010-01-05 1996-07-31
Post-translational Modifications PhosphoGRID | PhosphoPep Database
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000005016

RNH201 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for RNH201

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for RNH201]

1) Frank P, et al.  (1998) Yeast RNase H(35) is the counterpart of the mammalian RNase HI, and is evolutionarily related to prokaryotic RNase HII. FEBS Lett 421(1):23-6
2) Qiu J, et al.  (1999) Saccharomyces cerevisiae RNase H(35) functions in RNA primer removal during lagging-strand DNA synthesis, most efficiently in cooperation with Rad27 nuclease. Mol Cell Biol 19(12):8361-71
3) Crow YJ, et al.  (2006) Mutations in genes encoding ribonuclease H2 subunits cause Aicardi-Goutieres syndrome and mimic congenital viral brain infection. Nat Genet 38(8):910-6