RMT2/YDR465C Summary Help

Standard Name RMT2 1
Systematic Name YDR465C
Feature Type ORF, Verified
Description Arginine N5 methyltransferase; methylates ribosomal protein Rpl12 (L12) on Arg67; relative distribution to the nucleus increases upon DNA replication stress (1, 2, 3)
Name Description aRginine MeThyltransferase 1
Chromosomal Location
ChrIV:1394574 to 1393336 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All RMT2 GO evidence and references
  View Computational GO annotations for RMT2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 2 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
28 total interaction(s) for 21 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 2
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 7
  • Co-purification: 1
  • Two-hybrid: 2

Genetic Interactions
  • Negative Genetic: 12
  • Positive Genetic: 2
  • Synthetic Growth Defect: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 412
Molecular Weight (Da) 47,469
Isoelectric Point (pI) 4.27
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:1394574 to 1393336 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1239 1394574..1393336 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002873
References cited on this page View Complete Literature Guide for RMT2
1) Niewmierzycka A and Clarke S  (1999) S-Adenosylmethionine-dependent methylation in Saccharomyces cerevisiae. Identification of a novel protein arginine methyltransferase. J Biol Chem 274(2):814-24
2) Chern MK, et al.  (2002) Yeast ribosomal protein L12 is a substrate of protein-arginine methyltransferase 2. J Biol Chem 277(18):15345-53
3) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76