RML2/YEL050C Summary Help

Standard Name RML2 1
Systematic Name YEL050C
Feature Type ORF, Verified
Description Mitochondrial ribosomal protein of the large subunit (L2); has similarity to E. coli L2 ribosomal protein; mutant allele (fat21) causes inability to utilize oleate, and induce oleic acid oxidation; may interfere with activity of the Adr1p transcription factor (1, 2, 3, 4)
Name Description Ribosomal Mitochondrial Large 1
Chromosomal Location
ChrV:60851 to 59670 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All RML2 GO evidence and references
  View Computational GO annotations for RML2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 4 genes
Resources
Classical genetics
conditional
null
Large-scale survey
null
overexpression
Resources
302 total interaction(s) for 295 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 4
  • Affinity Capture-RNA: 1
  • Biochemical Activity: 1
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 194
  • Positive Genetic: 83
  • Synthetic Growth Defect: 13
  • Synthetic Lethality: 4

Resources
Expression Summary
histogram
Resources
Length (a.a.) 393
Molecular Weight (Da) 43,786
Isoelectric Point (pI) 11.5
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrV:60851 to 59670 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1182 60851..59670 1996-07-31 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000776
References cited on this page View Complete Literature Guide for RML2
1) Pan C and Mason TL  (1997) Functional analysis of ribosomal protein L2 in yeast mitochondria. J Biol Chem 272(13):8165-71
2) Trotter PJ, et al.  (1999) A yeast strain defective in oleic acid utilization has a mutation in the RML2 gene. Biochim Biophys Acta 1438(2):223-38
3) Graack HR and Wittmann-Liebold B  (1998) Mitochondrial ribosomal proteins (MRPs) of yeast. Biochem J 329 ( Pt 3)():433-48
4) Hagerman RA and Trotter PJ  (2001) A mutation in the yeast mitochondrial ribosomal protein Rml2p is associated with a defect in catalase gene expression. Mol Cell Biol Res Commun 4(5):299-306