THO2/YNL139C Summary Help

THO2 BASIC INFORMATION

Standard Name THO2 1
Systematic Name YNL139C
Alias ZRG13 2 , LDB5 , RLR1 3
Feature Type ORF, Verified
Description Subunit of the THO complex, which is required for efficient transcription elongation and involved in transcriptional elongation-associated recombination; required for LacZ RNA expression from certain plasmids (1, 3, 4, 5)
Name Description suppressor of the Transcriptional defect of Hpr1 by Overexpression 1
GO Annotations All THO2 GO evidence and references
    View Computational GO annotations for THO2
Molecular Function
Manually curated
High-throughput
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All THO2 Phenotype details and references
Classical genetics
null
Large-scale survey
null
Interactions THO2 All interactions details and references
97 total interaction(s) for 39 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 52
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 16
  • Co-purification: 4
  • Two-hybrid: 1
Genetic Interactions
  • Dosage Rescue: 2
  • Phenotypic Enhancement: 7
  • Synthetic Growth Defect: 2
  • Synthetic Lethality: 11
  • Synthetic Rescue: 1
Sequence Information
ChrXIV:365719 to 360926 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Last Update Coordinates: 2005-11-07 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..4794 365719..360926 2005-11-07 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000005083

THO2 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Protein Info & Structure
  • Localization Resources
  • Interactions
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  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for THO2

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for THO2]

1) Piruat JI and Aguilera A  (1998) A novel yeast gene, THO2, is involved in RNA pol II transcription and provides new evidence for transcriptional elongation-associated recombination. EMBO J 17(16):4859-72
2) Yuan DS  (2000) Zinc-regulated genes in Saccharomyces cerevisiae revealed by transposon tagging. Genetics 156(1):45-58
3) West RW Jr, et al.  (2000) RLR1 (THO2), required for expressing lacZ fusions in yeast, is conserved from yeast to humans and is a suppressor of SIN4. Gene 243(1-2):195-205
4) Chavez S, et al.  (2000) A protein complex containing Tho2, Hpr1, Mft1 and a novel protein, Thp2, connects transcription elongation with mitotic recombination in Saccharomyces cerevisiae. EMBO J 19(21):5824-34
5) Rondon AG, et al.  (2003) Molecular evidence that the eukaryotic THO/TREX complex is required for efficient transcription elongation. J Biol Chem 278(40):39037-43