Standard Name	RLI1 1
Systematic Name	YDR091C
Feature Type	ORF, Verified
Description	Essential iron-sulfur protein required for ribosome biogenesis and translation initiation and termination; facilitates binding of a multifactor complex (MFC) of initiation factors to the small ribosomal subunit; predicted ABC family ATPase; forms a complex with Lto1p and Yae1p that may be involved in protection of the ribosome from damage due to reactive oxygen species (2, 3, 4, 5)
Name Description	RNase L Inhibitor

Chromosomal Location	ChrIV:628534 to 626708 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for RLI1
Molecular Function
Manually curated	ATPase activity (ISS) iron ion binding (IDA)
Biological Process
Manually curated	ribosomal large subunit biogenesis (IMP) ribosomal subunit export from nucleus (IMP) translational initiation (IMP) translational termination (IGI, IPI)
Cellular Component
Manually curated	cytoplasm (IDA) cytosolic ribosome (IDA) nucleus (IDA)
High-throughput	cytoplasm (IDA)

Classical genetics
conditional	colony sectoring: increased
null	dessication resistance: increased
overexpression	resistance to nocodazole: decreased
reduction of function	inviable
Large-scale survey
conditional	heat sensitivity: increased
null	haploinsufficient inviable
overexpression	cell cycle progression: abnormal inviable
reduction of function	competitive fitness: increased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	150 total interaction(s) for 115 unique genes/features.
Physical Interactions	Affinity Capture-MS: 63 Affinity Capture-RNA: 2 Affinity Capture-Western: 12 Biochemical Activity: 2 PCA: 3 Two-hybrid: 3
Genetic Interactions	Dosage Rescue: 1 Negative Genetic: 27 Phenotypic Enhancement: 1 Positive Genetic: 33 Synthetic Growth Defect: 2 Synthetic Lethality: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIV:628534 to 626708 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1827 628534..626708 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002498