Standard Name	RKR1 1
Systematic Name	YMR247C
Alias	LTN1 2
Feature Type	ORF, Verified
Description	RING domain E3 ubiquitin ligase; involved in the ubiquitin-mediated degradation of non-stop proteins; functional connections to chromatin modification; nuclear protein that also co-localizes with ribosomes; homolog of mouse Listerin, whose mutation has been reported to cause neurodegeneration in mice (1, 2, 3)
Name Description	RING domain mutant Killed by rtf1 deletion 1

Chromosomal Location	ChrXIII:768039 to 763351 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for RKR1
Molecular Function
Manually curated	ribosome binding (IDA) ubiquitin-protein ligase activity (IDA)
Biological Process
Manually curated	chromatin modification (IGI) chromatin silencing at telomere (IMP) protein ubiquitination (IDA, IMP) ubiquitin-dependent protein catabolic process (IMP)
Cellular Component
Manually curated	nucleus (IDA) colocalizes_with ribosome (IDA)
High-throughput	colocalizes_with ribosome (IDA)

Classical genetics
null	auxotrophy resistance to hygromycin B: decreased resistance to geldanamycin: decreased resistance to (S)-azetidine-2-carboxylic acid: increased silencing: decreased viable
Large-scale survey
null	competitive fitness: decreased haploinsufficient Protein A-nonstop protein accumulation: increased resistance to caffeine: decreased resistance to amiodarone: decreased resistance to doxorubicin: decreased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	40 total interaction(s) for 33 unique genes/features.
Physical Interactions	Affinity Capture-MS: 4 Affinity Capture-RNA: 1 Two-hybrid: 1
Genetic Interactions	Dosage Rescue: 4 Negative Genetic: 1 Phenotypic Enhancement: 3 Phenotypic Suppression: 2 Synthetic Growth Defect: 20 Synthetic Lethality: 3 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIII:768039 to 763351 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..4689 768039..763351 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004861