RKM3/YBR030W Summary Help

Standard Name RKM3 1
Systematic Name YBR030W
Feature Type ORF, Verified
Description Ribosomal lysine methyltransferase; specific for monomethylation of Rpl42ap and Rpl42bp (lysine 40); nuclear SET domain containing protein; relocalizes to the cytosol in response to hypoxia (1, 2, 3)
Name Description Ribosomal lysine (K) Methyltransferase 4
Chromosomal Location
ChrII:298292 to 299950 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All RKM3 GO evidence and references
  View Computational GO annotations for RKM3
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 6 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
unspecified
Resources
30 total interaction(s) for 27 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 3
  • Affinity Capture-RNA: 1
  • Two-hybrid: 1

Genetic Interactions
  • Negative Genetic: 16
  • Phenotypic Enhancement: 1
  • Positive Genetic: 5
  • Synthetic Growth Defect: 2
  • Synthetic Lethality: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 552
Molecular Weight (Da) 62,593
Isoelectric Point (pI) 4.37
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrII:298292 to 299950 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2004-07-16 | Sequence: 1997-01-28
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1659 298292..299950 2004-07-16 1997-01-28
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000234
References cited on this page View Complete Literature Guide for RKM3
1) Webb KJ, et al.  (2008) Identification of Two SET Domain Proteins Required for Methylation of Lysine Residues in Yeast Ribosomal Protein Rpl42ab. J Biol Chem 283(51):35561-8
2) Porras-Yakushi TR, et al.  (2006) A novel SET domain methyltransferase in yeast: Rkm2-dependent trimethylation of ribosomal protein L12ab at lysine 10. J Biol Chem 281(47):35835-45
3) Ghosh Dastidar R, et al.  (2012) The nuclear localization of SWI/SNF proteins is subjected to oxygen regulation. Cell Biosci 2(1):30
4) Porras-Yakushi TR, et al.  (2005) A novel SET domain methyltransferase modifies ribosomal protein Rpl23ab in yeast. J Biol Chem 280(41):34590-8