RIX1/YHR197W Summary Help

Standard Name RIX1 1
Systematic Name YHR197W
Alias IPI2 2
Feature Type ORF, Verified
Description Component of the Rix1 complex and possibly pre-replicative complexes; required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-replicative complex (pre-RC) formation and maintenance during DNA replication licensing; relocalizes to the cytosol in response to hypoxia; essential gene (1, 2, 3, 4, 5)
Name Description RIbosome eXport 1
Chromosomal Location
ChrVIII:493896 to 496187 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All RIX1 GO evidence and references
  View Computational GO annotations for RIX1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 5 genes
Resources
Classical genetics
conditional
null
repressible
Large-scale survey
conditional
null
overexpression
reduction of function
Resources
270 total interaction(s) for 97 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 159
  • Affinity Capture-RNA: 3
  • Affinity Capture-Western: 78
  • Co-crystal Structure: 1
  • Co-fractionation: 3
  • Co-purification: 19
  • Two-hybrid: 3

Genetic Interactions
  • Negative Genetic: 2
  • Positive Genetic: 1
  • Synthetic Lethality: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 763
Molecular Weight (Da) 86,739
Isoelectric Point (pI) 5.34
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVIII:493896 to 496187 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2005-11-07 | Sequence: 2011-02-03
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2292 493896..496187 2005-11-07 2011-02-03
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001240
References cited on this page View Complete Literature Guide for RIX1
1) Gadal O, et al.  (2001) Nuclear export of 60s ribosomal subunits depends on Xpo1p and requires a nuclear export sequence-containing factor, Nmd3p, that associates with the large subunit protein Rpl10p. Mol Cell Biol 21(10):3405-15
2) Krogan NJ, et al.  (2004) High-definition macromolecular composition of yeast RNA-processing complexes. Mol Cell 13(2):225-39
3) Nissan TA, et al.  (2004) A pre-ribosome with a tadpole-like structure functions in ATP-dependent maturation of 60S subunits. Mol Cell 15(2):295-301
4) Huo L, et al.  (2012) The Rix1 (Ipi1p-2p-3p) complex is a critical determinant of DNA replication licensing independent of their roles in ribosome biogenesis. Cell Cycle 11(7):1325-39
5) Ghosh Dastidar R, et al.  (2012) The nuclear localization of SWI/SNF proteins is subjected to oxygen regulation. Cell Biosci 2(1):30