RIM15/YFL033C Summary Help

Standard Name RIM15 1
Systematic Name YFL033C
Alias TAK1
Feature Type ORF, Verified
Description Protein kinase involved in cell proliferation in response to nutrients; glucose-repressible; involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; phosphorylates Igo1p and Igo2p; substrate of Pho80p-Pho85p kinase (2, 3, 4, 5, 6)
Name Description Regulator of IME2 1
Chromosomal Location
ChrVI:74427 to 69115 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All RIM15 GO evidence and references
  View Computational GO annotations for RIM15
Molecular Function
Manually curated
High-throughput
Biological Process
Manually curated
High-throughput
Cellular Component
Manually curated
High-throughput
Regulators 3 genes
Resources
Classical genetics
null
repressible
unspecified
Large-scale survey
null
overexpression
Resources
296 total interaction(s) for 157 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 7
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 4
  • Biochemical Activity: 23
  • Two-hybrid: 2

Genetic Interactions
  • Dosage Growth Defect: 1
  • Dosage Lethality: 1
  • Dosage Rescue: 4
  • Negative Genetic: 192
  • Phenotypic Enhancement: 5
  • Phenotypic Suppression: 10
  • Positive Genetic: 32
  • Synthetic Growth Defect: 1
  • Synthetic Lethality: 2
  • Synthetic Rescue: 10

Resources
Expression Summary
histogram
Resources
Length (a.a.) 1,770
Molecular Weight (Da) 196,529
Isoelectric Point (pI) 6.43
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVI:74427 to 69115 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..5313 74427..69115 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001861
References cited on this page View Complete Literature Guide for RIM15
1) Su SS and Mitchell AP  (1993) Identification of functionally related genes that stimulate early meiotic gene expression in yeast. Genetics 133(1):67-77
2) Vidan S and Mitchell AP  (1997) Stimulation of yeast meiotic gene expression by the glucose-repressible protein kinase Rim15p. Mol Cell Biol 17(5):2688-97
3) Cameroni E, et al.  (2004) The novel yeast PAS kinase Rim 15 orchestrates G0-associated antioxidant defense mechanisms. Cell Cycle 3(4):462-8
4) Roosen J, et al.  (2005) PKA and Sch9 control a molecular switch important for the proper adaptation to nutrient availability. Mol Microbiol 55(3):862-80
5) Wanke V, et al.  (2005) Regulation of G0 entry by the Pho80-Pho85 cyclin-CDK complex. EMBO J 24(24):4271-8
6) Juanes MA, et al.  (2013) Budding Yeast Greatwall and Endosulfines Control Activity and Spatial Regulation of PP2A(Cdc55) for Timely Mitotic Progression. PLoS Genet 9(7):e1003575