RIM11/YMR139W Summary Help

Standard Name RIM11 1, 2
Systematic Name YMR139W
Alias GSK3 , MDS1
Feature Type ORF, Verified
Description Protein kinase; required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta; protein abundance increases in response to DNA replication stress; RIM11 has a paralog, MRK1, that arose from the whole genome duplication (3, 4, 5, 6, 7)
Name Description Regulator of IME2 1
Chromosomal Location
ChrXIII:546125 to 547237 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All RIM11 GO evidence and references
  View Computational GO annotations for RIM11
Molecular Function
Manually curated
High-throughput
Biological Process
Manually curated
High-throughput
Cellular Component
High-throughput
Regulators 6 genes
Resources
Classical genetics
null
unspecified
Large-scale survey
null
overexpression
Resources
163 total interaction(s) for 104 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 35
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 5
  • Biochemical Activity: 20
  • PCA: 3
  • Protein-RNA: 1
  • Reconstituted Complex: 11
  • Two-hybrid: 15

Genetic Interactions
  • Dosage Growth Defect: 2
  • Dosage Rescue: 5
  • Negative Genetic: 49
  • Phenotypic Enhancement: 2
  • Positive Genetic: 7
  • Synthetic Growth Defect: 3
  • Synthetic Rescue: 3

Resources
Expression Summary
histogram
Resources
Length (a.a.) 370
Molecular Weight (Da) 43,004
Isoelectric Point (pI) 6.51
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIII:546125 to 547237 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1113 546125..547237 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004747
References cited on this page View Complete Literature Guide for RIM11
1) Mitchell AP and Bowdish KS  (1992) Selection for early meiotic mutants in yeast. Genetics 131(1):65-72
2) Su SS and Mitchell AP  (1993) Identification of functionally related genes that stimulate early meiotic gene expression in yeast. Genetics 133(1):67-77
3) Malathi K, et al.  (1997) Interaction of yeast repressor-activator protein Ume6p with glycogen synthase kinase 3 homolog Rim11p. Mol Cell Biol 17(12):7230-6
4) Puziss JW, et al.  (1994) MDS1, a dosage suppressor of an mck1 mutant, encodes a putative yeast homolog of glycogen synthase kinase 3. Mol Cell Biol 14(1):831-9
5) Rubin-Bejerano I, et al.  (2004) The in vivo activity of Ime1, the key transcriptional activator of meiosis-specific genes in Saccharomyces cerevisiae, is inhibited by the cyclic AMP/protein kinase A signal pathway through the glycogen synthase kinase 3-beta homolog Rim11. Mol Cell Biol 24(16):6967-79
6) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
7) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76