Standard Name	RIM11 1, 2
Systematic Name	YMR139W
Alias	GSK3 , MDS1
Feature Type	ORF, Verified
Description	Protein kinase; required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta; protein abundance increases in response to DNA replication stress; RIM11 has a paralog, MRK1, that arose from the whole genome duplication (3, 4, 5, 6, 7)
Name Description	Regulator of IME2 1

Chromosomal Location	ChrXIII:546125 to 547237 | ORF Map | GBrowse

	View Computational GO annotations for RIM11
Molecular Function
Manually curated	protein serine/threonine kinase activity (IDA, ISS)
High-throughput	protein kinase activity (IDA)
Biological Process
Manually curated	ascospore formation (IMP) protein phosphorylation (IGI, ISS) proteolysis (IGI) response to stress (IGI, IMP)
High-throughput	protein phosphorylation (IDA)
Cellular Component
High-throughput	cytoplasm (IDA)

Regulatory modules	predicted: stressResponse (631, 517) predicted: cellcycle (287) predicted: stressResponse (631, 517) predicted: cellcycle (287)

Classical genetics
null	resistance to methotrexate: increased
unspecified	sporulation efficiency: decreased
Large-scale survey
null	competitive fitness: decreased endocytosis: decreased resistance to elesclomol-Cu: decreased resistance to quinine: decreased sporulation: absent sporulation efficiency: decreased starvation resistance: decreased viable
overexpression	filamentous growth: increased resistance to LY-83583: decreased resistance to sirolimus: increased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	154 total interaction(s) for 112 unique genes/features.
Physical Interactions	Affinity Capture-MS: 34 Affinity Capture-RNA: 2 Affinity Capture-Western: 5 Biochemical Activity: 20 PCA: 3 Protein-RNA: 1 Reconstituted Complex: 11 Two-hybrid: 15
Genetic Interactions	Dosage Growth Defect: 2 Dosage Rescue: 5 Negative Genetic: 42 Phenotypic Enhancement: 2 Positive Genetic: 6 Synthetic Growth Defect: 3 Synthetic Rescue: 3
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIII:546125 to 547237 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1113 546125..547237 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain CLIB382 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004747