Standard Name	RIC1 1
Systematic Name	YLR039C
Feature Type	ORF, Verified
Description	Protein involved in retrograde transport to the cis-Golgi network; forms heterodimer with Rgp1p that acts as a GTP exchange factor for Ypt6p; involved in transcription of rRNA and ribosomal protein genes (2, 3)
Name Description	RIbosome Control 1

Chromosomal Location	ChrXII:228596 to 225426 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for RIC1
Molecular Function
Manually curated	contributes_to guanyl-nucleotide exchange factor activity (IDA, IGI, IPI)
Biological Process
Manually curated	intracellular protein transport (IMP) retrograde transport, endosome to Golgi (IGI, IMP, IPI)
Cellular Component
Manually curated	Golgi membrane (IDA) guanyl-nucleotide exchange factor complex (IDA) nucleus (ISS) Ric1p-Rgp1p complex (IPI)

Classical genetics
null	Sys1p-GFP distribution: abnormal Arl1p-GFP distribution: abnormal Imh1p-GFP distribution: abnormal carboxypeptidase Y (Prc1p) modification: decreased resistance to bortezomib: increased
Large-scale survey
null	UV resistance: decreased acid pH resistance: decreased rubidium(1+) accumulation: decreased competitive fitness: decreased haploinsufficient heat sensitivity: increased metal resistance: decreased oxidative stress resistance: decreased Fus-Mid-GFP distribution: abnormal resistance to methyl methanesulfonate: decreased resistance to propolis extract: decreased resistance to hydrogen chloride: decreased resistance to acetic acid: decreased resistance to hygromycin B: decreased resistance to ethanol: decreased resistance to tirapazamine: decreased resistance to PM02734: decreased resistance to monensin: decreased resistance to amiodarone: decreased resistance to oxalic acid: decreased resistance to tunicamycin: increased resistance to methyl methanesulfonate: increased resistance to fenpropimorph: increased resistance to cycloheximide: decreased resistance to amitrole: decreased resistance to paromomycin: decreased resistance to 4-nitroquinoline N-oxide: decreased resistance to 4-chlorophenol: decreased resistance to spermine: decreased resistance to bleomycin: decreased resistance to caffeine: decreased resistance to fluconazole: decreased resistance to hydroxyurea: decreased resistance to mycophenolic acid: decreased resistance to sirolimus: decreased resistance to mefloquine: decreased resistance to ciclopirox olamine: decreased resistance to curcumin: decreased resistance to (S)-lactic acid: decreased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	1357 total interaction(s) for 670 unique genes/features.
Physical Interactions	Affinity Capture-MS: 16 Affinity Capture-RNA: 2 Affinity Capture-Western: 2 Two-hybrid: 1
Genetic Interactions	Dosage Rescue: 8 Negative Genetic: 780 Phenotypic Enhancement: 1 Phenotypic Suppression: 1 Positive Genetic: 356 Synthetic Growth Defect: 80 Synthetic Lethality: 108 Synthetic Rescue: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXII:228596 to 225426 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..3171 228596..225426 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004029