RHO5/YNL180C Summary Help

Standard Name RHO5 1
Systematic Name YNL180C
Alias YNS0 2
Feature Type ORF, Verified
Description Non-essential small GTPase of the Rho/Rac family of Ras-like proteins; regulated by phosphorylation and ubiquitination; likely involved in protein kinase C (Pkc1p)-dependent signal transduction pathway that controls cell integrity (3, 4, 5)
Name Description Ras HOmolog 1
Chromosomal Location
ChrXIV:300649 to 299654 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All RHO5 GO evidence and references
  View Computational GO annotations for RHO5
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 9 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
overexpression
Resources
21 total interaction(s) for 12 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 6
  • Affinity Capture-Western: 1
  • Biochemical Activity: 1
  • PCA: 1
  • Reconstituted Complex: 1
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Growth Defect: 1
  • Dosage Rescue: 2
  • Phenotypic Enhancement: 1
  • Phenotypic Suppression: 1
  • Synthetic Rescue: 5

Resources
Expression Summary
histogram
Resources
Length (a.a.) 331
Molecular Weight (Da) 36,818
Isoelectric Point (pI) 8.66
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIV:300649 to 299654 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1998-11-10
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..996 300649..299654 2011-02-03 1998-11-10
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005124
References cited on this page View Complete Literature Guide for RHO5
1) Roumanie O, et al.  (2001) Functional characterization of the Bag7, Lrg1 and Rgd2 RhoGAP proteins from Saccharomyces cerevisiae. FEBS Lett 506(2):149-56
2) Garcia-Ranea JA and Valencia A  (1998) Distribution and functional diversification of the ras superfamily in Saccharomyces cerevisiae. FEBS Lett 434(3):219-25
3) Ridley AJ  (1995) Rho-related proteins: actin cytoskeleton and cell cycle. Curr Opin Genet Dev 5(1):24-30
4) Schmitz HP, et al.  (2002) Rho5p downregulates the yeast cell integrity pathway. J Cell Sci 115(Pt 15):3139-48
5) Annan RB, et al.  (2008) Rho5p is involved in mediating the osmotic stress response in saccharomyces cerevisiae, and its activity is regulated via Msi1p and Npr1p by phosphorylation and ubiquitination. Eukaryot Cell 7(9):1441-9