Standard Name	RGT1
Systematic Name	YKL038W
Feature Type	ORF, Verified
Description	Glucose-responsive transcription factor; regulates expression of several glucose transporter (HXT) genes in response to glucose; binds to promoters and acts both as a transcriptional activator and repressor; RGT1 has a paralog, EDS1, that arose from the whole genome duplication (1, 2, 3)
Name Description	Restores Glucose Transport 4

Chromosomal Location	ChrXI:365605 to 369117 | ORF Map | GBrowse

	View Computational GO annotations for RGT1
Molecular Function
Manually curated	DNA binding (IDA, TAS) RNA polymerase II core promoter proximal region sequence-specific DNA binding (IDA) RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription (IDA) RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription (IMP, IPI)
High-throughput	sequence-specific DNA binding (IDA)
Biological Process
Manually curated	glucose metabolic process (IGI) glucose transport (IGI) negative regulation of transcription from RNA polymerase II promoter (IDA, IGI) positive regulation of transcription from RNA polymerase II promoter (IDA) regulation of glucose import (IEP)
Cellular Component
Manually curated	nucleus (IC, IDA)

Binding motifs	Predicted RGT1 Binding Site Locations
	CGGADNAWH 5 [Search intergenic regions for CGGADNAWH] CGGANNA 2 [Search intergenic regions for CGGANNA] CGGAWNAA 6 [Search intergenic regions for CGGAWNAA]
Resources	ScerTF | UniProbe | YEASTRACT | YeTFaSCo

Classical genetics
null	alkaline pH resistance: decreased cell size: decreased colony appearance: abnormal prion formation: decreased sporulation: abnormal viable
Large-scale survey
null	competitive fitness: increased resistance to 4-chlorophenol: decreased viable
overexpression	silencing: abnormal
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	69 total interaction(s) for 47 unique genes/features.
Physical Interactions	Affinity Capture-MS: 5 Affinity Capture-Western: 8 Biochemical Activity: 5 Reconstituted Complex: 1 Two-hybrid: 10
Genetic Interactions	Negative Genetic: 23 Phenotypic Enhancement: 4 Phenotypic Suppression: 2 Positive Genetic: 2 Synthetic Growth Defect: 2 Synthetic Rescue: 7
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXI:365605 to 369117 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..3513 365605..369117 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001521