Standard Name	RGR1
Systematic Name	YLR071C
Alias	MED14 1
Feature Type	ORF, Verified
Description	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for glucose repression, HO repression, RME1 repression and sporulation (2, 3, 4)
Name Description	Resistant to Glucose Repression 5

Chromosomal Location	ChrXII:278626 to 275378 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: 70 cM

	View Computational GO annotations for RGR1
Molecular Function
Manually curated	RNA polymerase II repressing transcription factor binding (IPI)
Biological Process
Manually curated	negative regulation of transcription from RNA polymerase II promoter (IMP) positive regulation of transcription from RNA polymerase II promoter (IMP)
Cellular Component
Manually curated	core mediator complex (IDA)

Classical genetics
null	heat sensitivity: increased utilization of carbon source: absent
overexpression	budding: abnormal cell cycle progression in G1 phase: abnormal cellular morphology: abnormal
unspecified	transposable element transposition: decreased
Large-scale survey
conditional	chromosome/plasmid maintenance: abnormal
null	inviable
overexpression	vegetative growth: decreased
reduction of function	competitive fitness: increased telomere length: decreased
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	213 total interaction(s) for 66 unique genes/features.
Physical Interactions	Affinity Capture-MS: 107 Affinity Capture-Western: 63 Biochemical Activity: 1 Co-purification: 18 Reconstituted Complex: 6 Two-hybrid: 2
Genetic Interactions	Dosage Growth Defect: 1 Dosage Lethality: 1 Dosage Rescue: 1 Phenotypic Enhancement: 4 Phenotypic Suppression: 1 Synthetic Lethality: 6 Synthetic Rescue: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXII:278626 to 275378 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: 70 cM
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..3249 278626..275378 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004061