RGP1/YDR137W Summary

RGP1 BASIC INFORMATION

Standard Name	RGP1 1
Systematic Name	YDR137W
Feature Type	ORF, Verified
Description	Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) that catalyzes nucleotide exchange on Ypt6p (2)
Name Description	Reduced Growth Phenotype

GO Annotations	All RGP1 GO evidence and references
	View Computational GO annotations for RGP1
Molecular Function
Manually curated	contributes_to guanyl-nucleotide exchange factor activity (IDA, IPI)
Biological Process
Manually curated	retrograde transport, endosome to Golgi (IMP, IPI)
Cellular Component
Manually curated	Golgi apparatus (IDA) Golgi membrane (IPI) guanyl-nucleotide exchange factor complex (IDA) Ric1p-Rgp1p complex (IPI)

Mutant Phenotype	All RGP1 Phenotype details and references
Classical genetics
null	carboxypeptidase Y (Prc1p) modification: decreased resistance to FK506: decreased
Large-scale survey
null	inositols excretion: increased competitive fitness: decreased heat sensitivity: increased metal resistance: decreased resistance to oxalic acid: decreased resistance to sulfanilamide: decreased resistance to monensin: decreased resistance to St. John's Wort extract: decreased resistance to cyclosporin A: decreased resistance to FK506: decreased resistance to rapamycin: decreased resistance to tunicamycin: decreased viable

Interactions	RGP1 All interactions details and references
	View additional details at BioGRID
	482 total interaction(s) for 293 unique genes/features.
Physical Interactions	Affinity Capture-MS: 11 Affinity Capture-RNA: 1 Affinity Capture-Western: 1 Biochemical Activity: 1
Genetic Interactions	Dosage Rescue: 1 Negative Genetic: 322 Positive Genetic: 111 Synthetic Growth Defect: 14 Synthetic Lethality: 20

Sequence Information

ChrIV:728257 to 730248 | |

Genetic position: 82 cM

Last Update

Coordinates: 2008-06-05 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1992	728257..730248	2008-06-05	1996-07-31

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000002544

RGP1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for RGP1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for RGP1]

1)	Aguilera, A. and Klein, H. (1992) Personal Communication, Mortimer Map Edition 11
2)	Siniossoglou S, et al. (2000) Ric1p and Rgp1p form a complex that catalyses nucleotide exchange on Ypt6p. EMBO J 19(18):4885-94

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