Standard Name	RGD1
Systematic Name	YBR260C
Feature Type	ORF, Verified
Description	GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization (1, 2)
Name Description	Related GAP Domain 1

Chromosomal Location	ChrII:734639 to 732639 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for RGD1
Molecular Function
Manually curated	phosphatidylinositol-3,5-bisphosphate binding (IDA, IMP) phosphatidylinositol-3-phosphate binding (IDA, IMP) phosphatidylinositol-4,5-bisphosphate binding (IDA) phosphatidylinositol-4-phosphate binding (IDA, IMP) phosphatidylinositol-5-phosphate binding (IDA, IMP) Rho GTPase activator activity (IDA, IGI)
Biological Process
Manually curated	osmosensory signaling pathway (IGI) response to acid (IMP)
Cellular Component
Manually curated	actin cortical patch (IDA) cellular bud (IDA)
High-throughput	mating projection tip (IDA)

Classical genetics
null	resistance to tunicamycin: decreased resistance to L-1,4-dithiothreitol: decreased resistance to mercaptoethanol: normal
Large-scale survey
null	chitin deposition: normal competitive fitness: increased competitive fitness: decreased haploinsufficient resistance to (S)-lactic acid: decreased resistance to cadmium dichloride: decreased resistance to diltiazem-HCl: decreased resistance to tunicamycine: decreased resistance to Calcofluor White: normal resistance to tunicamycin: decreased resistance to camptothecin: decreased resistance to 1,4-dithiothreitol: decreased resistance to hydrogen chloride: decreased resistance to fluconazole: increased sporulation: normal stress resistance: decreased toxin resistance: increased viable
overexpression	vegetative growth: decreased rate vegetative growth: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	204 total interaction(s) for 143 unique genes/features.
Physical Interactions	Affinity Capture-MS: 10 Affinity Capture-Western: 2 Biochemical Activity: 1 Two-hybrid: 14
Genetic Interactions	Dosage Lethality: 1 Dosage Rescue: 7 Negative Genetic: 137 Phenotypic Enhancement: 1 Phenotypic Suppression: 1 Positive Genetic: 7 Synthetic Growth Defect: 7 Synthetic Lethality: 13 Synthetic Rescue: 3
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrII:734639 to 732639 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2001 734639..732639 2011-02-03 1997-01-28
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000464