RGC1/YPR115W Summary Help

Standard Name RGC1 1
Systematic Name YPR115W
Feature Type ORF, Verified
Description Pleckstrin homology domain containing protein; proposed to function as a glycerol channel activator; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; RGC1 has a paralog, ASK10, that arose from the whole genome duplication (1, 2, 3, 4)
Name Description Regulator of the Glycerol Channel 1
Chromosomal Location
ChrXVI:754877 to 758128 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All RGC1 GO evidence and references
  View Computational GO annotations for RGC1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Regulators 7 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
unspecified
Resources
69 total interaction(s) for 57 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 32
  • Affinity Capture-RNA: 1
  • Biochemical Activity: 10
  • PCA: 1
  • Reconstituted Complex: 4
  • Two-hybrid: 4

Genetic Interactions
  • Dosage Rescue: 2
  • Negative Genetic: 9
  • Phenotypic Enhancement: 2
  • Positive Genetic: 2
  • Synthetic Growth Defect: 1
  • Synthetic Lethality: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 1,083
Molecular Weight (Da) 120,394
Isoelectric Point (pI) 10.05
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXVI:754877 to 758128 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..3252 754877..758128 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Retired NameGCA1
Primary SGDIDS000006319
References cited on this page View Complete Literature Guide for RGC1
1) Beese SE, et al.  (2009) Identification of positive regulators of the yeast fps1 glycerol channel. PLoS Genet 5(11):e1000738
2) Kumar A, et al.  (2002) Subcellular localization of the yeast proteome. Genes Dev 16(6):707-19
3) Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91
4) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61