Standard Name	RGA2 1
Systematic Name	YDR379W
Feature Type	ORF, Verified
Description	GTPase-activating protein for polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; regulated by Pho85p and Cdc28p; RGA2 has a paralog, RGA1, that arose from the whole genome duplication (1, 2, 3)
Name Description	Rho GTPase Activating Protein 1

Chromosomal Location	ChrIV:1230167 to 1233196 | ORF Map | GBrowse

	View Computational GO annotations for RGA2
Molecular Function
Manually curated	Rho GTPase activator activity (IDA, IGI, IPI, ISA)
Biological Process
Manually curated	actin filament organization (ISS) budding cell apical bud growth (ISS) budding cell isotropic bud growth (ISS) establishment of cell polarity (TAS) invasive growth in response to glucose limitation (ISS) pheromone-dependent signal transduction involved in conjugation with cellular fusion (TAS) pseudohyphal growth (ISS) small GTPase mediated signal transduction (TAS)
Cellular Component
Manually curated	cellular bud neck split septin rings (IDA)

Classical genetics
null	Kss1p modification: increased
overexpression	cellular morphology: abnormal utilization of carbon source: absent
Large-scale survey
null	auxotrophy budding index: decreased competitive fitness: increased resistance to benzo[a]pyrene: increased vacuolar morphology: abnormal viable
overexpression	vegetative growth: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	55 total interaction(s) for 43 unique genes/features.
Physical Interactions	Affinity Capture-MS: 14 Affinity Capture-RNA: 1 Affinity Capture-Western: 2 Biochemical Activity: 5 PCA: 3 Two-hybrid: 6
Genetic Interactions	Dosage Growth Defect: 1 Dosage Lethality: 3 Dosage Rescue: 2 Negative Genetic: 11 Phenotypic Enhancement: 1 Positive Genetic: 1 Synthetic Growth Defect: 4 Synthetic Lethality: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIV:1230167 to 1233196 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..3030 1230167..1233196 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002787