Standard Name	RFC3
Systematic Name	YNL290W
Feature Type	ORF, Verified
Description	Subunit of heteropentameric Replication factor C (RF-C); which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon; relocalizes to the cytosol in response to hypoxia (1, 2, 3)
Name Description	Replication Factor C 1

Chromosomal Location	ChrXIV:86218 to 87240 | ORF Map | GBrowse

	View Computational GO annotations for RFC3
Molecular Function
Manually curated	ATPase activity (IDA) contributes_to DNA clamp loader activity (IDA)
Biological Process
Manually curated	leading strand elongation (IDA) mismatch repair (TAS) sister chromatid cohesion (IPI)
Cellular Component
Manually curated	Ctf18 RFC-like complex (IPI) cytosol (IDA) DNA replication factor C complex (IDA) Elg1 RFC-like complex (IPI) nucleus (IDA) Rad17 RFC-like complex (IDA)
High-throughput	nucleus (IDA)

Large-scale survey
null	inviable starvation resistance: decreased
reduction of function	competitive fitness: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	128 total interaction(s) for 79 unique genes/features.
Physical Interactions	Affinity Capture-MS: 43 Affinity Capture-RNA: 3 Affinity Capture-Western: 14 Co-fractionation: 1 Co-purification: 6 FRET: 1 PCA: 3 Reconstituted Complex: 6 Two-hybrid: 2
Genetic Interactions	Negative Genetic: 44 Positive Genetic: 2 Synthetic Lethality: 2 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIV:86218 to 87240 | ORF Map | GBrowse
Last Update	Coordinates: 2005-11-07 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1023 86218..87240 2005-11-07 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005234