Standard Name	RFC2 1
Systematic Name	YJR068W
Feature Type	ORF, Verified
Description	Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon (2, 3)
Name Description	Replication Factor C 2

Chromosomal Location	ChrX:567643 to 568704 | ORF Map | GBrowse

	View Computational GO annotations for RFC2
Molecular Function
Manually curated	contributes_to DNA clamp loader activity (IDA) purine nucleotide binding (ISS)
Biological Process
Manually curated	cell cycle checkpoint (IMP) leading strand elongation (IDA) mismatch repair (TAS) sister chromatid cohesion (IPI)
Cellular Component
Manually curated	Ctf18 RFC-like complex (IPI) DNA replication factor C complex (IDA) Elg1 RFC-like complex (IPI) Rad17 RFC-like complex (IDA)

Classical genetics
conditional	UV resistance: decreased cell cycle progression in S phase: abnormal chromosome/plasmid maintenance: decreased heat sensitivity: increased resistance to hydroxyurea: decreased resistance to methyl methanesulfonate: decreased spindle morphology: abnormal
overexpression	colony sectoring: increased mitotic recombination: increased resistance to hydroxyurea: decreased
reduction of function	UV resistance: decreased resistance to methyl methanesulfonate: decreased resistance to hydroxyurea: decreased vegetative growth: decreased rate
repressible	chromosome/plasmid maintenance: decreased
Large-scale survey
conditional	chromosome/plasmid maintenance: abnormal colony sectoring: increased
null	inviable resistance to sulfanilamide: decreased
overexpression	colony sectoring: increased
reduction of function	competitive fitness: decreased
repressible	cell cycle progression in G2 phase: abnormal chromosome/plasmid maintenance: decreased
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	103 total interaction(s) for 47 unique genes/features.
Physical Interactions	Affinity Capture-MS: 42 Affinity Capture-RNA: 2 Affinity Capture-Western: 15 Co-purification: 18 FRET: 1 PCA: 2 Reconstituted Complex: 7 Two-hybrid: 4
Genetic Interactions	Dosage Rescue: 1 Negative Genetic: 2 Synthetic Growth Defect: 2 Synthetic Lethality: 6 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrX:567643 to 568704 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1062 567643..568704 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003829