REC8/YPR007C Summary Help

Standard Name REC8 1
Systematic Name YPR007C
Alias SPO69 2
Feature Type ORF, Verified
Description Meiosis-specific component of sister chromatid cohesion complex; maintains cohesion between sister chromatids during meiosis I; maintains cohesion between centromeres of sister chromatids until meiosis II; independent of its role in sister chromatid cohesion, Rec8p promotes allelic collisions and prevents nonspecific chromosome interactions; homolog of S. pombe Rec8p (1, 3, 4)
Name Description RECombination
Chromosomal Location
ChrXVI:571378 to 569336 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All REC8 GO evidence and references
  View Computational GO annotations for REC8
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 2 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
43 total interaction(s) for 29 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 12
  • Affinity Capture-Western: 2
  • Biochemical Activity: 1
  • Co-localization: 3
  • Co-purification: 3
  • Two-hybrid: 1

Genetic Interactions
  • Negative Genetic: 7
  • Phenotypic Enhancement: 8
  • Phenotypic Suppression: 4
  • Synthetic Growth Defect: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 680
Molecular Weight (Da) 77,201
Isoelectric Point (pI) 4.91
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXVI:571378 to 569336 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2043 571378..569336 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000006211
References cited on this page View Complete Literature Guide for REC8
1) Klein F, et al.  (1999) A central role for cohesins in sister chromatid cohesion, formation of axial elements, and recombination during yeast meiosis. Cell 98(1):91-103
2) Chu S, et al.  (1998) The transcriptional program of sporulation in budding yeast. Science 282(5389):699-705
3) Buonomo SB, et al.  (2000) Disjunction of homologous chromosomes in meiosis I depends on proteolytic cleavage of the meiotic cohesin Rec8 by separin. Cell 103(3):387-98
4) Lui DY, et al.  (2013) Multiple opposing constraints govern chromosome interactions during meiosis. PLoS Genet 9(1):e1003197