REB1/YBR049C Summary Help

Standard Name REB1 1
Systematic Name YBR049C
Alias GRF2
Feature Type ORF, Verified
Description RNA polymerase I enhancer binding protein; DNA binding protein that binds to genes transcribed by both RNA polymerase I and RNA polymerase II; required for termination of RNA polymerase I transcription; REB1 has a paralog, NSI1, that arose from the whole genome duplication (1, 2)
Name Description RNA polymerase I Enhancer Binding protein 1
Chromosomal Location
ChrII:336818 to 334386 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All REB1 GO evidence and references
  View Computational GO annotations for REB1
Molecular Function
High-throughput
Biological Process
Manually curated
Cellular Component
Manually curated
Targets 3144 genes
Regulators 93 genes
Resources
Large-scale survey
conditional
null
reduction of function
Resources
68 total interaction(s) for 54 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 45
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 2
  • Co-purification: 1
  • PCA: 3

Genetic Interactions
  • Negative Genetic: 15
  • Synthetic Growth Defect: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 810
Molecular Weight (Da) 91,874
Isoelectric Point (pI) 4.83
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrII:336818 to 334386 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2433 336818..334386 2011-02-03 1997-01-28
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000253
References cited on this page View Complete Literature Guide for REB1
1) Morrow BE, et al.  (1989) Proteins that bind to the yeast rDNA enhancer. J Biol Chem 264(15):9061-8
2) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
3) Liaw PC and Brandl CJ  (1994) Defining the sequence specificity of the Saccharomyces cerevisiae DNA binding protein REB1p by selecting binding sites from random-sequence oligonucleotides. Yeast 10(6):771-87
4) Badis G, et al.  (2008) A library of yeast transcription factor motifs reveals a widespread function for Rsc3 in targeting nucleosome exclusion at promoters. Mol Cell 32(6):878-87
5) Harbison CT, et al.  (2004) Transcriptional regulatory code of a eukaryotic genome. Nature 431(7004):99-104