Standard Name	REB1
Systematic Name	YBR049C
Alias	GRF2
Feature Type	ORF, Verified
Description	RNA polymerase I enhancer binding protein; DNA binding protein that binds to genes transcribed by both RNA polymerase I and RNA polymerase II; required for termination of RNA polymerase I transcription; REB1 has a paralog, NSI1, that arose from the whole genome duplication (1, 2)
Name Description	RNA polymerase I Enhancer Binding protein 1

Chromosomal Location	ChrII:336818 to 334386 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for REB1
Molecular Function
High-throughput	sequence-specific DNA binding (IDA)
Biological Process
Manually curated	regulation of transcription from RNA polymerase II promoter (TAS) termination of RNA polymerase I transcription (TAS)
Cellular Component
Manually curated	nucleoplasm (IDA)

Binding motifs	Predicted REB1 Binding Site Locations
	CGGGTRR 3 [Search intergenic regions for CGGGTRR] RTTACCCK 4 [Search intergenic regions for RTTACCCK] TTACCCG 5 [Search intergenic regions for TTACCCG]
Regulatory modules	predicted: cellcycle (233)
Resources	ScerTF | YEASTRACT | YeTFaSCo

Large-scale survey
conditional	heat sensitivity: increased
null	filamentous growth: decreased haploinsufficient invasive growth: absent inviable
reduction of function	resistance to benomyl: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	66 total interaction(s) for 54 unique genes/features.
Physical Interactions	Affinity Capture-MS: 43 Affinity Capture-RNA: 1 Affinity Capture-Western: 2 Co-purification: 1 PCA: 3
Genetic Interactions	Negative Genetic: 15 Synthetic Growth Defect: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrII:336818 to 334386 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2433 336818..334386 2011-02-03 1997-01-28
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000253