RDS2/YPL133C Summary Help

Standard Name RDS2 1
Systematic Name YPL133C
Feature Type ORF, Verified
Description Transcription factor involved in regulating gluconeogenesis; also involved in the regulation of glyoxylate cycle genes; member of the zinc cluster family of proteins; confers resistance to ketoconazole (1, 2, 3)
Name Description Regulator of Drug Sensitivity 1
Chromosomal Location
ChrXVI:301228 to 299888 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All RDS2 GO evidence and references
  View Computational GO annotations for RDS2
Molecular Function
Manually curated
High-throughput
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Targets 11 genes
Regulators 1 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
Resources
35 total interaction(s) for 32 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Biochemical Activity: 10
  • Reconstituted Complex: 10
  • Two-hybrid: 5

Genetic Interactions
  • Negative Genetic: 6
  • Phenotypic Enhancement: 1
  • Positive Genetic: 1
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 446
Molecular Weight (Da) 50,081
Isoelectric Point (pI) 7.63
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXVI:301228 to 299888 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1341 301228..299888 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000006054
References cited on this page View Complete Literature Guide for RDS2
1) Akache B and Turcotte B  (2002) New regulators of drug sensitivity in the family of yeast zinc cluster proteins. J Biol Chem 277(24):21254-60
2) Soontorngun N, et al.  (2007) Regulation of Gluconeogenesis in Saccharomyces cerevisiae Is Mediated by Activator and Repressor Functions of Rds2. Mol Cell Biol 27(22):7895-905
3) Turcotte B, et al.  (2010) Transcriptional regulation of nonfermentable carbon utilization in budding yeast. FEMS Yeast Res 10(1):2-13
4) Zhu C, et al.  (2009) High-resolution DNA-binding specificity analysis of yeast transcription factors. Genome Res 19(4):556-66
5) Badis G, et al.  (2008) A library of yeast transcription factor motifs reveals a widespread function for Rsc3 in targeting nucleosome exclusion at promoters. Mol Cell 32(6):878-87