RDI1/YDL135C Summary Help

Standard Name RDI1 1
Systematic Name YDL135C
Feature Type ORF, Verified
Description Rho GDP dissociation inhibitor; involved in the localization and regulation of Cdc42p and Rho1p; protein abundance increases in response to DNA replication stress (1, 2, 3, 4)
Name Description Rho GDP Dissociation Inhibitor 5
Chromosomal Location
ChrIV:219288 to 218680 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All RDI1 GO evidence and references
  View Computational GO annotations for RDI1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 5 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
overexpression
Resources
97 total interaction(s) for 79 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 3
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 4
  • Biochemical Activity: 2
  • FRET: 1
  • PCA: 2
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Growth Defect: 3
  • Dosage Lethality: 3
  • Negative Genetic: 69
  • Phenotypic Enhancement: 3
  • Phenotypic Suppression: 1
  • Positive Genetic: 2
  • Synthetic Lethality: 1
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 202
Molecular Weight (Da) 23,138
Isoelectric Point (pI) 5.89
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:219288 to 218680 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..609 219288..218680 1996-07-31 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002294
References cited on this page View Complete Literature Guide for RDI1
1) Koch G, et al.  (1997) Association of the Rho family small GTP-binding proteins with Rho GDP dissociation inhibitor (Rho GDI) in Saccharomyces cerevisiae. Oncogene 15(4):417-22
2) Richman TJ, et al.  (2004) Analysis of cell-cycle specific localization of the Rdi1p RhoGDI and the structural determinants required for Cdc42p membrane localization and clustering at sites of polarized growth. Curr Genet 45(6):339-49
3) Logan MR, et al.  (2011) Functional analysis of RhoGDI inhibitory activity on vacuole membrane fusion. Biochem J 434(3):445-57
4) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76
5) Masuda T, et al.  (1994) Molecular cloning and characterization of yeast rho GDP dissociation inhibitor. J Biol Chem 269(31):19713-8