AFT1/YGL071W Summary Help

AFT1 BASIC INFORMATION

Standard Name AFT1 1
Systematic Name YGL071W
Alias RCS1 2
Feature Type ORF, Verified
Description Transcription factor involved in iron utilization and homeostasis; binds the consensus site PyPuCACCCPu and activates the expression of target genes in response to changes in iron availability (3, 4)
Name Description Activator of Ferrous Transport 1
GO Annotations All AFT1 GO evidence and references
    View Computational GO annotations for AFT1
Molecular Function
Manually curated
High-throughput
Biological Process
Manually curated
Cellular Component
Manually curated
Regulatory Role
Regulatory modules predicted: stressResponse ( 529 )
Mutant Phenotype All AFT1 Phenotype details and references
Classical genetics
activation
null
Large-scale survey
null
Interactions AFT1 All interactions details and references
55 total interaction(s) for 35 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 7
  • Protein-RNA: 1
  • Reconstituted Complex: 6
  • Two-hybrid: 12
Genetic Interactions
  • Dosage Rescue: 2
  • Phenotypic Enhancement: 4
  • Phenotypic Suppression: 1
  • Synthetic Growth Defect: 20
  • Synthetic Rescue: 1
Sequence Information
ChrVII:372015 to 374087 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 2004-07-20 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..2073 372015..374087 2004-07-20 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000003039

AFT1 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
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  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for AFT1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for AFT1]

1) Yamaguchi-Iwai Y, et al.  (1995) AFT1: a mediator of iron regulated transcriptional control in Saccharomyces cerevisiae. EMBO J 14(6):1231-9
2) Gil R, et al.  (1991) RCS1, a gene involved in controlling cell size in Saccharomyces cerevisiae. Yeast 7(1):1-14
3) Yamaguchi-Iwai Y, et al.  (1996) Iron-regulated DNA binding by the AFT1 protein controls the iron regulon in yeast. EMBO J 15(13):3377-84
4) Shakoury-Elizeh M, et al.  (2004) Transcriptional remodeling in response to iron deprivation in Saccharomyces cerevisiae. Mol Biol Cell 15(3):1233-43