Standard Name	RCO1 1, 2, 3
Systematic Name	YMR075W
Feature Type	ORF, Verified
Description	Essential subunit of the histone deacetylase Rpd3S complex; interacts with Eaf3p (2, 3, 4)

Chromosomal Location	ChrXIII:413982 to 416036 | ORF Map | GBrowse

	View Computational GO annotations for RCO1
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	histone deacetylation (IMP) negative regulation of antisense RNA transcription (IMP) regulation of DNA-dependent DNA replication initiation (IMP) transcription elongation from RNA polymerase II promoter (IGI)
Cellular Component
Manually curated	histone deacetylase complex (IDA) Rpd3L complex (IDA) Rpd3S complex (IDA)
High-throughput	nucleus (IDA)

Resources	YeTFaSCo

Classical genetics
null	viable
Large-scale survey
null	competitive fitness: decreased heat sensitivity: increased lifespan: increased Rad52-YFP distribution: increased resistance to cycloheximide: decreased resistance to fluconazole: decreased resistance to hydroxyurea: decreased resistance to caffeine: decreased stress resistance: increased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	387 total interaction(s) for 238 unique genes/features.
Physical Interactions	Affinity Capture-MS: 55 Affinity Capture-RNA: 3 Affinity Capture-Western: 12 Reconstituted Complex: 2
Genetic Interactions	Dosage Lethality: 1 Negative Genetic: 255 Phenotypic Enhancement: 5 Phenotypic Suppression: 6 Positive Genetic: 28 Synthetic Growth Defect: 7 Synthetic Lethality: 1 Synthetic Rescue: 12
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIII:413982 to 416036 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2055 413982..416036 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004680