RCO1/YMR075W Summary Help

Standard Name RCO1 1, 2, 3
Systematic Name YMR075W
Feature Type ORF, Verified
Description Essential component of the Rpd3S histone deacetylase complex; interacts with Eaf3p (2, 3, 4)
Chromosomal Location
ChrXIII:413982 to 416036 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All RCO1 GO evidence and references
  View Computational GO annotations for RCO1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 1 genes
Resources
Classical genetics
null
Large-scale survey
null
repressible
Resources
387 total interaction(s) for 237 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 55
  • Affinity Capture-RNA: 3
  • Affinity Capture-Western: 12
  • Reconstituted Complex: 2

Genetic Interactions
  • Dosage Lethality: 1
  • Negative Genetic: 255
  • Phenotypic Enhancement: 5
  • Phenotypic Suppression: 6
  • Positive Genetic: 28
  • Synthetic Growth Defect: 7
  • Synthetic Lethality: 1
  • Synthetic Rescue: 12

Resources
Expression Summary
histogram
Resources
Length (a.a.) 684
Molecular Weight (Da) 78,836
Isoelectric Point (pI) 9.16
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIII:413982 to 416036 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2055 413982..416036 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004680
References cited on this page View Complete Literature Guide for RCO1
1) Schaft, D, et al.  (2002) personal communication
2) Carrozza MJ, et al.  (2005) Histone H3 methylation by Set2 directs deacetylation of coding regions by Rpd3S to suppress spurious intragenic transcription. Cell 123(4):581-92
3) Keogh MC, et al.  (2005) Cotranscriptional set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complex. Cell 123(4):593-605
4) Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91