RCE1/YMR274C Summary Help

Standard Name RCE1 1
Systematic Name YMR274C
Feature Type ORF, Verified
Description Type II CAAX prenyl protease; involved in the proteolysis and maturation of Ras and the a-factor mating pheromone (1, 2, 3)
Name Description Ras and a-factor Converting Enzyme 1
Chromosomal Location
ChrXIII:815311 to 814364 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All RCE1 GO evidence and references
  View Computational GO annotations for RCE1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 2 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
Resources
105 total interaction(s) for 57 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 1
  • PCA: 2
  • Protein-RNA: 1

Genetic Interactions
  • Negative Genetic: 73
  • Phenotypic Enhancement: 8
  • Phenotypic Suppression: 1
  • Positive Genetic: 5
  • Synthetic Growth Defect: 9
  • Synthetic Lethality: 5

Resources
Expression Summary
histogram
Resources
Length (a.a.) 315
Molecular Weight (Da) 35,911
Isoelectric Point (pI) 9.02
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIII:815311 to 814364 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..948 815311..814364 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004887
References cited on this page View Complete Literature Guide for RCE1
1) Boyartchuk VL, et al.  (1997) Modulation of Ras and a-factor function by carboxyl-terminal proteolysis. Science 275(5307):1796-800
2) Trueblood CE, et al.  (2000) The CaaX proteases, Afc1p and Rce1p, have overlapping but distinct substrate specificities. Mol Cell Biol 20(12):4381-92
3) Pei J and Grishin NV  (2001) Type II CAAX prenyl endopeptidases belong to a novel superfamily of putative membrane-bound metalloproteases. Trends Biochem Sci 26(5):275-7