Standard Name	RCE1 1
Systematic Name	YMR274C
Feature Type	ORF, Verified
Description	Type II CAAX prenyl protease involved in the proteolysis and maturation of Ras and the a-factor mating pheromone (1, 2, 3)
Name Description	Ras and a-factor Converting Enzyme 1

Chromosomal Location	ChrXIII:815311 to 814364 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for RCE1
Molecular Function
Manually curated	metalloendopeptidase activity (IDA, IMP)
Biological Process
Manually curated	CAAX-box protein processing (IMP) peptide pheromone maturation (IMP) protein processing (IDA)
Cellular Component
Manually curated	integral to endoplasmic reticulum membrane (IDA)
High-throughput	integral to membrane (ISM)

Classical genetics
null	mating response: decreased pheromone production: decreased GFP-Ras2p distribution: abnormal viable
Large-scale survey
null	competitive fitness: increased competitive fitness: decreased haploinsufficient protein transport: abnormal resistance to streptomycin: decreased resistance to amitrole: decreased resistance to dimethyl sulfoxide: decreased resistance to cycloheximide: decreased vacuolar morphology: abnormal viable
overexpression	vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	105 total interaction(s) for 57 unique genes/features.
Physical Interactions	Affinity Capture-RNA: 1 PCA: 2 Protein-RNA: 1
Genetic Interactions	Negative Genetic: 73 Phenotypic Enhancement: 8 Phenotypic Suppression: 1 Positive Genetic: 5 Synthetic Growth Defect: 9 Synthetic Lethality: 5
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIII:815311 to 814364 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..948 815311..814364 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain CLIB382 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004887