RAS1/YOR101W Summary Help

Standard Name RAS1
Systematic Name YOR101W
Feature Type ORF, Verified
Description GTPase involved in G-protein signaling in adenylate cyclase activation; plays a role in cell proliferation; localized to the plasma membrane; homolog of mammalian RAS proto-oncogenes; relative distribution to the nucleus increases upon DNA replication stress; RAS1 has a paralog, RAS2, that arose from the whole genome duplication (1, 2, 3, 4, 5)
Name Description homologous to RAS proto-oncogene
Chromosomal Location
ChrXV:515244 to 516173 | ORF Map | GBrowse
Gbrowse
Genetic position: 53 cM
Gene Ontology Annotations All RAS1 GO evidence and references
  View Computational GO annotations for RAS1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 8 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
overexpression
Resources
85 total interaction(s) for 49 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 5
  • Affinity Capture-RNA: 1
  • Biochemical Activity: 1
  • Reconstituted Complex: 4
  • Two-hybrid: 4

Genetic Interactions
  • Dosage Growth Defect: 1
  • Dosage Lethality: 2
  • Dosage Rescue: 19
  • Negative Genetic: 13
  • Phenotypic Enhancement: 2
  • Positive Genetic: 9
  • Synthetic Growth Defect: 2
  • Synthetic Lethality: 5
  • Synthetic Rescue: 17

Resources
Expression Summary
histogram
Resources
Length (a.a.) 309
Molecular Weight (Da) 34,346
Isoelectric Point (pI) 5.08
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXV:515244 to 516173 | ORF Map | GBrowse
SGD ORF map
Genetic position: 53 cM
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..930 515244..516173 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005627
References cited on this page View Complete Literature Guide for RAS1
1) Fujiyama A and Tamanoi F  (1986) Processing and fatty acid acylation of RAS1 and RAS2 proteins in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 83(5):1266-70
2) Broek D, et al.  (1985) Differential activation of yeast adenylate cyclase by wild-type and mutant RAS proteins. Cell 41(3):763-9
3) Kataoka T, et al.  (1984) Genetic analysis of yeast RAS1 and RAS2 genes. Cell 37(2):437-45
4) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
5) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76