RAS1/YOR101W Summary

RAS1 BASIC INFORMATION

Standard Name	RAS1
Systematic Name	YOR101W
Feature Type	ORF, Verified
Description	GTPase involved in G-protein signaling in the adenylate cyclase activating pathway, plays a role in cell proliferation; localized to the plasma membrane; homolog of mammalian RAS proto-oncogenes (1, 2, 3)
Name Description	homologous to RAS proto-oncogene

GO Annotations	All RAS1 GO evidence and references
	View Computational GO annotations for RAS1
Molecular Function
Manually curated	GTPase activity (IMP)
Biological Process
Manually curated	activation of adenylate cyclase activity by G-protein signaling pathway (IDA) cell proliferation (IMP) Ras protein signal transduction (TAS) replicative cell aging (IMP)
Cellular Component
Manually curated	plasma membrane (IDA)

Regulatory Role
Regulatory modules	predicted: cellcycle ( 287 )

Mutant Phenotype	All RAS1 Phenotype details and references
Classical genetics
null	replicative lifespan: increased
overexpression	replicative lifespan: normal
Large-scale survey
null	replicative lifespan: increased viable

Interactions	RAS1 All interactions details and references
	56 total interaction(s) for 30 unique genes/features.
Physical Interactions	Affinity Capture-MS: 3 Biochemical Activity: 1 Reconstituted Complex: 3 Two-hybrid: 4
Genetic Interactions	Dosage Lethality: 2 Dosage Rescue: 17 Phenotypic Enhancement: 4 Phenotypic Suppression: 6 Synthetic Growth Defect: 1 Synthetic Lethality: 5 Synthetic Rescue: 10

Sequence Information

ChrXV:515245 to 516174 | |

Genetic position: 53 cM

Last Update

Coordinates: 2006-01-05 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..930	515245..516174	2006-01-05	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000005627

RAS1 RESOURCES

Click on map for expanded view

SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for RAS1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for RAS1]

1)	Fujiyama A and Tamanoi F (1986) Processing and fatty acid acylation of RAS1 and RAS2 proteins in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 83(5):1266-70
2)	Broek D, et al. (1985) Differential activation of yeast adenylate cyclase by wild-type and mutant RAS proteins. Cell 41(3):763-9
3)	Kataoka T, et al. (1984) Genetic analysis of yeast RAS1 and RAS2 genes. Cell 37(2):437-45

SGD^tm pages Database Copyright © 1997-2010 The Board of Trustees of Leland Stanford Junior University. Permission to use the information contained in this database was given by the researchers/institutes who contributed or published the information. Users of the database are solely responsible for compliance with any copyright restrictions, including those applying to the author abstracts. Documents from this server are provided "AS-IS" without any warranty, expressed or implied. The SGD project at Stanford University is supported by a Genome Research Resource Grant from the US National Human Genome Research Institute, part of the US National Institutes of Health.