Standard Name	RAS1
Systematic Name	YOR101W
Feature Type	ORF, Verified
Description	GTPase involved in G-protein signaling in adenylate cyclase activation; plays a role in cell proliferation; localized to the plasma membrane; homolog of mammalian RAS proto-oncogenes; relative distribution to the nucleus increases upon DNA replication stress; RAS1 has a paralog, RAS2, that arose from the whole genome duplication (1, 2, 3, 4, 5)
Name Description	homologous to RAS proto-oncogene

Chromosomal Location	ChrXV:515244 to 516173 | ORF Map | GBrowse
	Genetic position: 53 cM

	View Computational GO annotations for RAS1
Molecular Function
Manually curated	GTPase activity (IMP)
Biological Process
Manually curated	adenylate cyclase-activating G-protein coupled receptor signaling pathway (IDA) Ras protein signal transduction (TAS) replicative cell aging (IMP)
Cellular Component
Manually curated	plasma membrane (IDA)
High-throughput	cytoplasm (IDA) nucleus (IDA)

Regulatory modules	predicted: cellcycle (287)

Classical genetics
null	metal resistance: decreased replicative lifespan: increased
overexpression	replicative lifespan: normal
Large-scale survey
null	competitive fitness: increased replicative lifespan: increased resistance to cycloheximide: increased resistance to tunicamycin: increased resistance to hydroxyurea: decreased resistance to tirapazamine: increased starvation resistance: decreased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	84 total interaction(s) for 48 unique genes/features.
Physical Interactions	Affinity Capture-MS: 4 Affinity Capture-RNA: 1 Biochemical Activity: 1 Reconstituted Complex: 4 Two-hybrid: 4
Genetic Interactions	Dosage Growth Defect: 1 Dosage Lethality: 2 Dosage Rescue: 19 Negative Genetic: 13 Phenotypic Enhancement: 2 Positive Genetic: 9 Synthetic Growth Defect: 2 Synthetic Lethality: 5 Synthetic Rescue: 17
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXV:515244 to 516173 | ORF Map | GBrowse
	Genetic position: 53 cM
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..930 515244..516173 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005627