Standard Name	RAI1 1
Systematic Name	YGL246C
Feature Type	ORF, Verified
Description	Nuclear protein with decapping endonuclease activity; targets mRNAs with unmethylated 7-methylguanosine cap structures; binds to and stabilizes the exoribonuclease Rat1p; required for pre-rRNA processing; relocalizes to the cytosol in response to hypoxia; homologous to human DOM3Z (1, 2, 3, 4)
Name Description	Rat1p Interacting Protein 1

Chromosomal Location	ChrVII:38780 to 37617 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for RAI1
Molecular Function
Manually curated	enzyme regulator activity (IDA) pyrophosphatase activity (IDA)
Biological Process
Manually curated	maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) (IMP) maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) (IMP) nuclear-transcribed mRNA catabolic process (IDA, IMP) termination of RNA polymerase II transcription, poly(A)-coupled (IMP)
Cellular Component
Manually curated	cytosol (IDA) nucleus (IDA, IPI)

Classical genetics
null	aberrantly 5'-end-capped mRNA accumulation: increased vegetative growth: decreased
Large-scale survey
null	budding pattern: abnormal cell shape: abnormal cell size: decreased competitive fitness: decreased heat sensitivity: increased resistance to sodium arsenite: increased resistance to trichothecene: increased resistance to CTBT: decreased resistance to amiodarone: decreased resistance to pentachlorophenol: decreased resistance to dimethyl sulfoxide: decreased resistance to acrolein: decreased resistance to hygromycin B: decreased resistance to sorbate: decreased resistance to L-1,4-dithiothreitol: decreased sporulation: absent sporulation: decreased stress resistance: increased toxin resistance: increased utilization of carbon source: decreased utilization of phosphorus source: decreased vacuolar morphology: abnormal vegetative growth: decreased rate viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	83 total interaction(s) for 63 unique genes/features.
Physical Interactions	Affinity Capture-MS: 54 Affinity Capture-RNA: 2 Affinity Capture-Western: 5 Biochemical Activity: 3
Genetic Interactions	Dosage Rescue: 2 Negative Genetic: 7 Phenotypic Enhancement: 1 Phenotypic Suppression: 1 Positive Genetic: 1 Synthetic Growth Defect: 2 Synthetic Lethality: 5
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVII:38780 to 37617 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1164 38780..37617 1996-07-31 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003215