Standard Name	RAD59
Systematic Name	YDL059C
Feature Type	ORF, Verified
Description	Protein involved DNA double-strand break repair; repairs breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; forms nuclear foci upon DNA replication stress; required for loading of Rad52p to DSBs; paralog of Rad52p (1, 2, 3, 4, 5)
Name Description	RADiation sensitive

Chromosomal Location	ChrIV:344953 to 344237 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for RAD59
Molecular Function
Manually curated	protein binding (IPI)
Biological Process
Manually curated	DNA strand renaturation (IDA) double-strand break repair via single-strand annealing (IGI) telomere maintenance via recombination (IMP)
Cellular Component
Manually curated	nucleus (IGI)
High-throughput	cytoplasm (IDA) nucleus (IDA)

Classical genetics
null	chromosome/plasmid maintenance: abnormal mutation frequency: increased Rad52p accumulation: absent resistance to hydroxyurea: decreased
Large-scale survey
null	UV resistance: decreased competitive fitness: decreased gamma ray resistance: decreased haploproficient heat sensitivity: increased mitotic recombination: increased oxidative stress resistance: decreased Rad52-YFP distribution: increased resistance to methyl methanesulfonate: decreased resistance to tirapazamine: decreased resistance to camptothecin: decreased resistance to hydroxyurea: decreased resistance to sodium selenide: decreased resistance to doxorubicin: decreased resistance to cisplatin: decreased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	151 total interaction(s) for 103 unique genes/features.
Physical Interactions	Affinity Capture-MS: 33 Affinity Capture-Western: 11 Co-localization: 1 Reconstituted Complex: 3 Two-hybrid: 4
Genetic Interactions	Dosage Lethality: 1 Dosage Rescue: 1 Negative Genetic: 18 Phenotypic Enhancement: 23 Phenotypic Suppression: 15 Positive Genetic: 3 Synthetic Growth Defect: 29 Synthetic Lethality: 6 Synthetic Rescue: 3
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIV:344953 to 344237 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2004-02-11 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..717 344953..344237 2004-02-11 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002217