RAD17/YOR368W Summary Help

Standard Name RAD17
Systematic Name YOR368W
Feature Type ORF, Verified
Description Checkpoint protein; involved in the activation of the DNA damage and meiotic pachytene checkpoints; with Mec3p and Ddc1p, forms a clamp that is loaded onto partial duplex DNA; homolog of human and S. pombe Rad1 and U. maydis Rec1 proteins (1, 2, 3, 4)
Name Description RADiation sensitive
Chromosomal Location
ChrXV:1026843 to 1028048 | ORF Map | GBrowse
Gbrowse
Genetic position: 214 cM
Gene Ontology Annotations All RAD17 GO evidence and references
  View Computational GO annotations for RAD17
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 3 genes
Resources
Classical genetics
null
reduction of function
unspecified
Large-scale survey
null
Resources
252 total interaction(s) for 133 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 5
  • Affinity Capture-Western: 8
  • Co-fractionation: 4
  • Co-purification: 3
  • Reconstituted Complex: 2
  • Two-hybrid: 10

Genetic Interactions
  • Dosage Growth Defect: 2
  • Dosage Lethality: 1
  • Dosage Rescue: 2
  • Negative Genetic: 66
  • Phenotypic Enhancement: 26
  • Phenotypic Suppression: 13
  • Positive Genetic: 19
  • Synthetic Growth Defect: 57
  • Synthetic Lethality: 17
  • Synthetic Rescue: 17

Resources
Expression Summary
histogram
Resources
Length (a.a.) 401
Molecular Weight (Da) 45,579
Isoelectric Point (pI) 5.02
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXV:1026843 to 1028048 | ORF Map | GBrowse
SGD ORF map
Genetic position: 214 cM
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1206 1026843..1028048 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005895
References cited on this page View Complete Literature Guide for RAD17
1) Parker AE, et al.  (1998) A human homologue of the Schizosaccharomyces pombe rad1+ checkpoint gene encodes an exonuclease. J Biol Chem 273(29):18332-9
2) Lydall D, et al.  (1996) A meiotic recombination checkpoint controlled by mitotic checkpoint genes. Nature 383(6603):840-3
3) Majka J and Burgers PM  (2003) Yeast Rad17/Mec3/Ddc1: a sliding clamp for the DNA damage checkpoint. Proc Natl Acad Sci U S A 100(5):2249-54
4) Shinohara M, et al.  (2003) The mitotic DNA damage checkpoint proteins Rad17 and Rad24 are required for repair of double-strand breaks during meiosis in yeast. Genetics 164(3):855-65