Standard Name	PUB1 1 (see Nomenclature conflict Note)
Systematic Name	YNL016W
Alias	RNP1 2
Feature Type	ORF, Verified
Description	Poly (A)+ RNA-binding protein; abundant mRNP-component protein that binds mRNA and is required for stability of many mRNAs; component of glucose deprivation induced stress granules, involved in P-body-dependent granule assembly; protein abundance increases in response to DNA replication stress (1, 3, 4, 5, 6)
Name Description	PolyUridylate Binding 1

Chromosomal Location	ChrXIV:602907 to 604268 | ORF Map | GBrowse

	View Computational GO annotations for PUB1
Molecular Function
Manually curated	mRNA binding (IDA, IMP) poly(U) RNA binding (IDA)
Biological Process
Manually curated	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (IDA) regulation of mRNA stability (IMP) stress granule assembly (IMP)
Cellular Component
Manually curated	cytoplasm (IDA) cytoplasmic stress granule (IDA) nucleus (IDA)

Classical genetics
null	Gag accumulation: decreased stress resistance: decreased viable
Large-scale survey
null	competitive fitness: decreased endocytosis: decreased haploinsufficient resistance to caffeine: increased resistance to fenpropimorph: increased resistance to fluconazole: increased resistance to benzo[a]pyrene: decreased resistance to camptothecin: decreased stress resistance: decreased transposable element transposition: decreased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	145 total interaction(s) for 120 unique genes/features.
Physical Interactions	Affinity Capture-MS: 22 Affinity Capture-RNA: 4 Affinity Capture-Western: 3 PCA: 15 Reconstituted Complex: 3 Two-hybrid: 5
Genetic Interactions	Negative Genetic: 74 Phenotypic Suppression: 1 Positive Genetic: 10 Synthetic Growth Defect: 7 Synthetic Lethality: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIV:602907 to 604268 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1362 602907..604268 2011-02-03 1997-01-28
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB382 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004961