PIL1/YGR086C Summary Help

PIL1 BASIC INFORMATION

Standard Name PIL1 1, 2
Systematic Name YGR086C
Feature Type ORF, Verified
Description Primary component of eisosomes, which are large immobile cell cortex structures associated with endocytosis; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways; detected in phosphorylated state in mitochondria (2, 3, 4)
Name Description Phosphorylation Inhibited by Long chain bases 2
GO Annotations All PIL1 GO evidence and references
    View Computational GO annotations for PIL1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Mutant Phenotype All PIL1 Phenotype details and references
Classical genetics
null
reduction of function
Large-scale survey
null
Interactions PIL1 All interactions details and references
129 total interaction(s) for 96 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 69
  • Affinity Capture-RNA: 2
  • Biochemical Activity: 2
  • Two-hybrid: 7
Genetic Interactions
  • Phenotypic Enhancement: 31
  • Phenotypic Suppression: 16
  • Synthetic Haploinsufficiency: 1
  • Synthetic Rescue: 1
Sequence Information
ChrVII:650621 to 649602 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Last Update Coordinates: 2004-07-20 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1020 650621..649602 2004-07-20 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000003318

PIL1 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for PIL1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for PIL1]

1) Samanta MP and Liang S  (2003) Predicting protein functions from redundancies in large-scale protein interaction networks. Proc Natl Acad Sci U S A 100(22):12579-83
2) Zhang X, et al.  (2004) Pil1p and Lsp1p negatively regulate the 3-phosphoinositide-dependent protein kinase-like kinase Pkh1p and downstream signaling pathways Pkc1p and Ypk1p. J Biol Chem 279(21):22030-8
3) Walther TC, et al.  (2006) Eisosomes mark static sites of endocytosis. Nature 439(7079):998-1003
4) Reinders J, et al.  (2007) Profiling phosphoproteins of yeast mitochondria reveals a role of phosphorylation in assembly of the ATP synthase. Mol Cell Proteomics 6(11):1896-906