Standard Name	PXR1
Systematic Name	YGR280C
Alias	GNO1 1
Feature Type	ORF, Verified
Description	Essential protein involved in rRNA and snoRNA maturation; competes with TLC1 RNA for binding to Est2p, suggesting a role in negative regulation of telomerase; human homolog inhibits telomerase; contains a G-patch RNA interacting domain (1, 2, 3)
Name Description	PinX1-Related gene
Gene Product Alias	PinX1 3

Chromosomal Location	ChrVII:1051725 to 1050910 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for PXR1
Molecular Function
Manually curated	NOT telomerase inhibitor activity (IMP) telomerase inhibitor activity (IGI, IMP, IPI)
Biological Process
Manually curated	box C/D snoRNA 3'-end processing (IMP) negative regulation of telomere maintenance via telomerase (IGI, IMP, IPI)
Cellular Component
Manually curated	nucleolus (IDA) nucleoplasm (IDA)

Classical genetics
null	mature 25S rRNA accumulation: decreased 32S rRNA processing intermediate accumulation: decreased U18 snoRNA accumulation: abnormal aberrant 23S rRNA processing intermediate accumulation: increased 35S pre-rRNA accumulation: increased U24 snoRNA accumulation: abnormal mature 18S rRNA accumulation: decreased inviable Sqs1p accumulation: decreased Ltv1p accumulation: increased telomere length: decreased vegetative growth: decreased viable
overexpression	telomere length: decreased
Large-scale survey
null	haploinsufficient inviable vegetative growth: normal
overexpression	vegetative growth: decreased vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	26 total interaction(s) for 24 unique genes/features.
Physical Interactions	Affinity Capture-MS: 7 Affinity Capture-RNA: 2 Affinity Capture-Western: 1 PCA: 6 Two-hybrid: 3
Genetic Interactions	Negative Genetic: 4 Phenotypic Enhancement: 1 Synthetic Growth Defect: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVII:1051725 to 1050910 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..816 1051725..1050910 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003512