PXA2/YKL188C Summary Help

PXA2 BASIC INFORMATION

Standard Name PXA2
Systematic Name YKL188C
Alias PAT1
Feature Type ORF, Verified
Description Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter and ALD-related proteins (1, 2, 3, 4)
Name Description PeroXisomal ABC-transporter 4
GO Annotations All PXA2 GO evidence and references
    View Computational GO annotations for PXA2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All PXA2 Phenotype details and references
Large-scale survey
null
Interactions PXA2 All interactions details and references
6 total interaction(s) for 6 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 1
  • Two-hybrid: 2
Genetic Interactions
  • Phenotypic Enhancement: 1
  • Synthetic Lethality: 1
Sequence Information
ChrXI:88791 to 86230 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Last Update Coordinates: 2004-02-13 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..2562 88791..86230 2004-02-13 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | TCDB | UniProtKB
Primary SGDIDS000001671

PXA2 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Localization Resources
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  • Functional Analysis

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Expression Summary histogram

ADDITIONAL INFORMATION for PXA2

NOMENCLATURE CONFLICT NOTE

NameRelevanceDescription
GNA1Nomenclature conflictPAT1 has been used in the literature to refer to both PXA2/YKL188C, which encodes a ABC transporter-2, and GNA1/YFL017C, which encodes a glucosamine-phosphate N-acetyltransferase.
PAT1Nomenclature conflictPAT1 has been used in the literature to refer to both PAT1/YCR077C, which is involved in translational initiation and chromosome segregation, and PXA2/YKL188C, which encodes a ABC transporter-2.

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for PXA2]

1) Verleur N, et al.  (1997) Transport of activated fatty acids by the peroxisomal ATP-binding-cassette transporter Pxa2 in a semi-intact yeast cell system. Eur J Biochem 249(3):657-61
2) Shani N, et al.  (1996) An S. cerevisiae peroxisomal transporter, orthologous to the human adrenoleukodystrophy protein, appears to be a heterodimer of two half ABC transporters: Pxa1p and Pxa2p. Ann N Y Acad Sci 804:770-2
3) Hettema EH, et al.  (1996) The ABC transporter proteins Pat1 and Pat2 are required for import of long-chain fatty acids into peroxisomes of Saccharomyces cerevisiae. EMBO J 15(15):3813-22
4) Shani N and Valle D  (1996) A Saccharomyces cerevisiae homolog of the human adrenoleukodystrophy transporter is a heterodimer of two half ATP-binding cassette transporters. Proc Natl Acad Sci U S A 93(21):11901-6