PUP1/YOR157C Summary Help

PUP1 BASIC INFORMATION

Standard Name PUP1 1
Systematic Name YOR157C
Feature Type ORF, Verified
Description Beta 2 subunit of the 20S proteasome; endopeptidase with trypsin-like activity that cleaves after basic residues; synthesized as a proprotein before being proteolytically processed for assembly into 20S particle; human homolog is subunit Z (2, 3, 4)
Name Description PUtative Proteasome subunit 1
GO Annotations All PUP1 GO evidence and references
    View Computational GO annotations for PUP1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All PUP1 Phenotype details and references
Classical genetics
conditional
reduction of function
Large-scale survey
null
Interactions PUP1 All interactions details and references
109 total interaction(s) for 39 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 35
  • Affinity Capture-Western: 11
  • Co-crystal Structure: 5
  • Co-fractionation: 1
  • Co-purification: 1
  • Two-hybrid: 6
Genetic Interactions
  • Phenotypic Enhancement: 1
  • Synthetic Growth Defect: 20
  • Synthetic Lethality: 1
  • Synthetic Rescue: 28
Sequence Information
ChrXV:631752 to 630967 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Genetic position: 84.6 cM
Last Update Coordinates: 2006-01-05 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..786 631752..630967 2006-01-05 1996-07-31
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000005683

PUP1 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
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  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

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Expression Summary histogram

ADDITIONAL INFORMATION for PUP1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for PUP1]

1) Haffter P and Fox TD  (1991) Nucleotide sequence of PUP1 encoding a putative proteasome subunit in Saccharomyces cerevisiae. Nucleic Acids Res 19(18):5075
2) Groll M, et al.  (1997) Structure of 20S proteasome from yeast at 2.4 A resolution. Nature 386(6624):463-71
3) Jager S, et al.  (1999) Proteasome beta-type subunits: unequal roles of propeptides in core particle maturation and a hierarchy of active site function. J Mol Biol 291(4):997-1013
4) Nussbaum AK, et al.  (1998) Cleavage motifs of the yeast 20S proteasome beta subunits deduced from digests of enolase 1. Proc Natl Acad Sci U S A 95(21):12504-9