PUG1/YER185W Summary Help

Standard Name PUG1 1
Systematic Name YER185W
Feature Type ORF, Verified
Description Plasma membrane protein involved in protoprophyrin and heme transport; roles in the uptake of protoprophyrin IX and the efflux of heme; expression is induced under both low-heme and low-oxygen conditions; member of the fungal lipid-translocating exporter (LTE) family of proteins (1, 2, 3)
Name Description Protoporphyrin Uptake Gene 1
Chromosomal Location
ChrV:559454 to 560365 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All PUG1 GO evidence and references
  View Computational GO annotations for PUG1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 6 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
1 total interaction(s) for 1 unique genes/features.
Genetic Interactions
  • Negative Genetic: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 303
Molecular Weight (Da) 33,732
Isoelectric Point (pI) 9.26
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrV:559454 to 560365 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..912 559454..560365 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000987
References cited on this page View Complete Literature Guide for PUG1
1) Protchenko O, et al.  (2008) Role of PUG1 in inducible porphyrin and heme transport in Saccharomyces cerevisiae. Eukaryot Cell 7(5):859-71
2) Kim H, et al.  (2003) Topology models for 37 Saccharomyces cerevisiae membrane proteins based on C-terminal reporter fusions and predictions. J Biol Chem 278(12):10208-13
3) Manente M and Ghislain M  (2009) The lipid-translocating exporter family and membrane phospholipid homeostasis in yeast. FEMS Yeast Res 9(5):673-87