MPT5/YGL178W Summary Help

MPT5 BASIC INFORMATION

Standard Name MPT5
Systematic Name YGL178W
Alias HTR1 , PUF5 , UTH4
Feature Type ORF, Verified
Description Member of the Puf family of RNA-binding proteins; binds to mRNAs encoding chromatin modifiers and spindle pole body components; involved in longevity, maintenance of cell wall integrity, and sensitivity to and recovery from pheromone arrest (1, 2, 3, 4, 5)
Name Description Multicopy suppressor of Pop Two 6
GO Annotations All MPT5 GO evidence and references
    View Computational GO annotations for MPT5
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Mutant Phenotype All MPT5 Phenotype details and references
Classical genetics
null
unspecified
Interactions MPT5 All interactions details and references
49 total interaction(s) for 31 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 2
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 5
  • PCA: 9
  • Protein-RNA: 3
  • Two-hybrid: 10
Genetic Interactions
  • Dosage Rescue: 9
  • Phenotypic Enhancement: 3
  • Phenotypic Suppression: 1
  • Synthetic Growth Defect: 1
  • Synthetic Lethality: 3
  • Synthetic Rescue: 2
Sequence Information
ChrVII:167358 to 170577 | ORF Map | GBrowse
This feature contains embedded feature(s): YGL177W
Gbrowse
Last Update Coordinates: 2004-07-20 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..3 167358..167360 2004-07-20 1996-07-31
Intron 4..643 167361..168000 2004-07-20 1996-07-31
CDS 644..3220 168001..170577 2004-07-20 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000003146

MPT5 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for MPT5

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for MPT5]

1) Kennedy BK, et al.  (1997) Redistribution of silencing proteins from telomeres to the nucleolus is associated with extension of life span in S. cerevisiae. Cell 89(3):381-91
2) Chen T and Kurjan J  (1997) Saccharomyces cerevisiae Mpt5p interacts with Sst2p and plays roles in pheromone sensitivity and recovery from pheromone arrest. Mol Cell Biol 17(6):3429-39
3) Tadauchi T, et al.  (2001) Post-transcriptional regulation through the HO 3'-UTR by Mpt5, a yeast homolog of Pumilio and FBF. EMBO J 20(3):552-61
4) Kaeberlein M and Guarente L  (2002) Saccharomyces cerevisiae MPT5 and SSD1 function in parallel pathways to promote cell wall integrity. Genetics 160(1):83-95
5) Gerber AP, et al.  (2004) Extensive association of functionally and cytotopically related mRNAs with Puf family RNA-binding proteins in yeast. PLoS Biol 2(3):E79
6) Hata H, et al.  (1998) Dhh1p, a putative RNA helicase, associates with the general transcription factors Pop2p and Ccr4p from Saccharomyces cerevisiae. Genetics 148(2):571-9