PTR3/YFR029W Summary Help

Standard Name PTR3 1
Systematic Name YFR029W
Alias SSY3 2 , RAA2 3
Feature Type ORF, Verified
Description Component of the SPS plasma membrane amino acid sensor system; senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes; other members are Ssy1p, Ptr3p, and Ssy5p (4, 5)
Name Description Peptide TRansport 1
Chromosomal Location
ChrVI:210937 to 212973 | ORF Map | GBrowse
Gbrowse
Genetic position: 46 cM
Gene Ontology Annotations All PTR3 GO evidence and references
  View Computational GO annotations for PTR3
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 2 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
reduction of function
Resources
86 total interaction(s) for 74 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 5
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 2
  • Biochemical Activity: 3
  • Protein-RNA: 1
  • Two-hybrid: 6

Genetic Interactions
  • Dosage Rescue: 4
  • Negative Genetic: 46
  • Phenotypic Enhancement: 2
  • Phenotypic Suppression: 1
  • Positive Genetic: 1
  • Synthetic Lethality: 2
  • Synthetic Rescue: 12

Resources
Expression Summary
histogram
Resources
Length (a.a.) 678
Molecular Weight (Da) 76,285
Isoelectric Point (pI) 7.39
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVI:210937 to 212973 | ORF Map | GBrowse
SGD ORF map
Genetic position: 46 cM
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2037 210937..212973 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001925
References cited on this page View Complete Literature Guide for PTR3
1) Island MD, et al.  (1991) Isolation and characterization of S. cerevisiae mutants deficient in amino acid-inducible peptide transport. Curr Genet 20(6):457-63
2) Jorgensen MU, et al.  (1998) Mutations in five loci affecting GAP1-independent uptake of neutral amino acids in yeast. Yeast 14(2):103-14
3) McCusker JH and Haber JE  (1990) Mutations in Saccharomyces cerevisiae which confer resistance to several amino acid analogs. Mol Cell Biol 10(6):2941-9
4) Forsberg H and Ljungdahl PO  (2001) Genetic and biochemical analysis of the yeast plasma membrane Ssy1p-Ptr3p-Ssy5p sensor of extracellular amino acids. Mol Cell Biol 21(3):814-26
5) Forsberg H, et al.  (2001) The role of the yeast plasma membrane SPS nutrient sensor in the metabolic response to extracellular amino acids. Mol Microbiol 42(1):215-28