PTR2/YKR093W Summary Help

Standard Name PTR2 1
Systematic Name YKR093W
Feature Type ORF, Verified
Description Integral membrane peptide transporter; mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p (2, 3)
Name Description Peptide TRansport 4
Chromosomal Location
ChrXI:615730 to 617535 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All PTR2 GO evidence and references
  View Computational GO annotations for PTR2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 32 genes
Resources
Classical genetics
overexpression
Large-scale survey
null
overexpression
Resources
44 total interaction(s) for 40 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 3
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 1
  • Co-fractionation: 3
  • PCA: 5

Genetic Interactions
  • Dosage Growth Defect: 2
  • Dosage Lethality: 1
  • Dosage Rescue: 2
  • Negative Genetic: 17
  • Phenotypic Enhancement: 2
  • Positive Genetic: 4
  • Synthetic Growth Defect: 2
  • Synthetic Lethality: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 601
Molecular Weight (Da) 68,043
Isoelectric Point (pI) 5.14
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXI:615730 to 617535 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1806 615730..617535 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | TCDB | UniProtKB
Primary SGDIDS000001801
References cited on this page View Complete Literature Guide for PTR2
1) Island MD, et al.  (1991) Isolation and characterization of S. cerevisiae mutants deficient in amino acid-inducible peptide transport. Curr Genet 20(6):457-63
2) Byrd C, et al.  (1998) The N-end rule pathway controls the import of peptides through degradation of a transcriptional repressor. EMBO J 17(1):269-77
3) Hauser M, et al.  (2001) Multiplicity and regulation of genes encoding peptide transporters in Saccharomyces cerevisiae. Mol Membr Biol 18(1):105-12
4) Perry JR, et al.  (1994) Isolation and characterization of a Saccharomyces cerevisiae peptide transport gene. Mol Cell Biol 14(1):104-15