PTP2/YOR208W Summary Help

Standard Name PTP2
Systematic Name YOR208W
Feature Type ORF, Verified
Description Phosphotyrosine-specific protein phosphatase; involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the nucleus (1, 2, 3, 4)
Name Description Protein Tyrosine Phosphatase
Chromosomal Location
ChrXV:733925 to 736177 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All PTP2 GO evidence and references
  View Computational GO annotations for PTP2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 3 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
overexpression
Resources
88 total interaction(s) for 48 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 5
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 5
  • Biochemical Activity: 7
  • Reconstituted Complex: 1
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Lethality: 2
  • Dosage Rescue: 7
  • Negative Genetic: 16
  • Phenotypic Enhancement: 8
  • Phenotypic Suppression: 2
  • Positive Genetic: 5
  • Synthetic Growth Defect: 8
  • Synthetic Haploinsufficiency: 1
  • Synthetic Lethality: 7
  • Synthetic Rescue: 12

Resources
Expression Summary
histogram
Resources
Length (a.a.) 750
Molecular Weight (Da) 85,868
Isoelectric Point (pI) 9.41
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXV:733925 to 736177 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2253 733925..736177 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005734
References cited on this page View Complete Literature Guide for PTP2
1) Mattison CP, et al.  (1999) Differential regulation of the cell wall integrity mitogen-activated protein kinase pathway in budding yeast by the protein tyrosine phosphatases Ptp2 and Ptp3. Mol Cell Biol 19(11):7651-60
2) Wurgler-Murphy SM, et al.  (1997) Regulation of the Saccharomyces cerevisiae HOG1 mitogen-activated protein kinase by the PTP2 and PTP3 protein tyrosine phosphatases. Mol Cell Biol 17(3):1289-97
3) Mattison CP and Ota IM  (2000) Two protein tyrosine phosphatases, Ptp2 and Ptp3, modulate the subcellular localization of the Hog1 MAP kinase in yeast. Genes Dev 14(10):1229-35
4) Winkler A, et al.  (2002) Heat stress activates the yeast high-osmolarity glycerol mitogen-activated protein kinase pathway, and protein tyrosine phosphatases are essential under heat stress. Eukaryot Cell 1(2):163-73