PTP1/YDL230W Summary Help

Standard Name PTP1
Systematic Name YDL230W
Feature Type ORF, Verified
Description Phosphotyrosine-specific protein phosphatase; dephosphorylates a broad range of substrates in vivo, including Fpr3p; localized to the cytoplasm and the mitochondria; proposed to be a negative regulator of filamentation (1, 2, 3)
Name Description Protein Tyrosine Phosphatase
Chromosomal Location
ChrIV:42700 to 43707 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All PTP1 GO evidence and references
  View Computational GO annotations for PTP1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Classical genetics
overexpression
Large-scale survey
null
Resources
77 total interaction(s) for 68 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 8
  • Affinity Capture-Western: 1
  • Biochemical Activity: 4
  • Protein-peptide: 5
  • Reconstituted Complex: 1

Genetic Interactions
  • Negative Genetic: 52
  • Positive Genetic: 6

Resources
Expression Summary
histogram
Resources
Length (a.a.) 335
Molecular Weight (Da) 38,868
Isoelectric Point (pI) 8.11
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:42700 to 43707 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1008 42700..43707 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002389
References cited on this page View Complete Literature Guide for PTP1
1) Wilson LK, et al.  (1995) The yeast immunophilin Fpr3 is a physiological substrate of the tyrosine-specific phosphoprotein phosphatase Ptp1. J Biol Chem 270(42):25185-93
2) Guan KL, et al.  (1991) Cloning and expression of a yeast protein tyrosine phosphatase. J Biol Chem 266(20):12964-70
3) Fasolo J, et al.  (2011) Diverse protein kinase interactions identified by protein microarrays reveal novel connections between cellular processes. Genes Dev 25(7):767-78