Standard Name	PTK2 1
Systematic Name	YJR059W
Alias	STK2 2
Feature Type	ORF, Verified
Description	Putative serine/threonine protein kinase; involved in regulation of ion transport across plasma membrane; enhances spermine uptake; PTK2 has a paralog, PTK1, that arose from the whole genome duplication (1, 3, 4)
Name Description	Putative serine/Threonine protein Kinase

Chromosomal Location	ChrX:545787 to 548243 | ORF Map | GBrowse

	View Computational GO annotations for PTK2
Molecular Function
Manually curated	protein kinase activity (IDA, ISS)
High-throughput	protein kinase activity (IDA)
Biological Process
Manually curated	cellular ion homeostasis (IGI, IMP) G1/S transition of mitotic cell cycle (IGI) polyamine transport (IGI, IMP)
High-throughput	protein phosphorylation (IDA) regulation of cell size (IMP)
Cellular Component
Manually curated	cytoplasm (IDA) nucleus (IDA) plasma membrane (IDA)

Classical genetics
null	glycogen accumulation: decreased dessication resistance: decreased killer toxin resistance: decreased Nup49p distribution: abnormal Nop1p distribution: abnormal Slt2p modification: increased resistance to hygromycin B: increased resistance to calcium dichloride: decreased resistance to Papulacandin B: increased toxin resistance: increased
unspecified	resistance to putrescine: increased resistance to spermidine: increased resistance to spermine: increased
Large-scale survey
null	cell size: decreased glycogen accumulation: decreased glutathione excretion: increased competitive fitness: increased competitive fitness: decreased dessication resistance: decreased metal resistance: decreased oxidative stress resistance: decreased resistance to hygromycin B: increased resistance to cycloheximide: decreased resistance to amitrole: decreased resistance to spermine: increased resistance to tetramethylammonium: increased resistance to bleomycin: increased resistance to cycloheximide: increased resistance to fenpropimorph: increased resistance to hydroxyurea: increased resistance to citric acid: decreased resistance to 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid: decreased resistance to ethanol: decreased resistance to tunicamycin: decreased resistance to 1,4-dithiothreitol: decreased resistance to caffeine: decreased resistance to fluconazole: decreased resistance to mycophenolic acid: decreased starvation resistance: decreased stress resistance: increased toxin resistance: decreased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	560 total interaction(s) for 507 unique genes/features.
Physical Interactions	Affinity Capture-MS: 13 Affinity Capture-RNA: 1 Biochemical Activity: 201 Reconstituted Complex: 5
Genetic Interactions	Dosage Growth Defect: 5 Dosage Lethality: 3 Dosage Rescue: 4 Negative Genetic: 282 Phenotypic Enhancement: 9 Phenotypic Suppression: 7 Positive Genetic: 25 Synthetic Growth Defect: 3 Synthetic Lethality: 1 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrX:545787 to 548243 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2457 545787..548243 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003820