PTK1/YKL198C Summary Help

Standard Name PTK1 1
Systematic Name YKL198C
Alias KKT8 , STK1 2 , YKL199C , YKT9 , POT1 3
Feature Type ORF, Verified
Description Putative serine/threonine protein kinase; regulates spermine uptake; involved in polyamine transport; possible mitochondrial protein; PTK1 has a paralog, PTK2, that arose from the whole genome duplication (1, 3, 4, 5)
Name Description Putative serine/Threonine protein Kinase
Chromosomal Location
ChrXI:70220 to 68232 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All PTK1 GO evidence and references
  View Computational GO annotations for PTK1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 4 genes
Resources
Large-scale survey
null
Resources
201 total interaction(s) for 85 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 13
  • Affinity Capture-RNA: 2

Genetic Interactions
  • Dosage Lethality: 2
  • Negative Genetic: 172
  • Positive Genetic: 11
  • Synthetic Growth Defect: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 662
Molecular Weight (Da) 73,502
Isoelectric Point (pI) 9.42
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXI:70220 to 68232 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
This feature contains embedded feature(s): YKL199C
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 2011-02-03
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1989 70220..68232 2011-02-03 2011-02-03
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001681
References cited on this page View Complete Literature Guide for PTK1
1) Nozaki T, et al.  (1996) A second gene encoding a putative serine/threonine protein kinase which enhances spermine uptake in Saccharomyces cerevisiae. Biochem Biophys Res Commun 228(2):452-8
2) Kaouass M, et al.  (1997) The STK2 gene, which encodes a putative Ser/Thr protein kinase, is required for high-affinity spermidine transport in Saccharomyces cerevisiae. Mol Cell Biol 17(6):2994-3004
3) Kakinuma Y, et al.  (1995) Cloning of the gene encoding a putative serine/threonine protein kinase which enhances spermine uptake in Saccharomyces cerevisiae. Biochem Biophys Res Commun 216(3):985-92
4) Tomaska L  (2000) Mitochondrial protein phosphorylation: lessons from yeasts. Gene 255(1):59-64
5) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61