PTI1/YGR156W Summary Help

Standard Name PTI1 1
Systematic Name YGR156W
Feature Type ORF, Verified
Description Essential component of CPF (cleavage and polyadenylation factor); involved in 3' end formation of snoRNA and mRNA; interacts directly with Pta1p; relocalizes to the cytosol in response to hypoxia; similar to mammalian Cleavage-Stimulation Factor CstF-64 (1, 2, 3, 4)
Name Description PTa1p Interacting protein 1
Chromosomal Location
ChrVII:800546 to 801823 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All PTI1 GO evidence and references
  View Computational GO annotations for PTI1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 4 genes
Resources
Large-scale survey
conditional
null
Resources
114 total interaction(s) for 46 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 77
  • Affinity Capture-RNA: 3
  • Affinity Capture-Western: 3
  • Far Western: 3
  • Reconstituted Complex: 1
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 17
  • Positive Genetic: 2
  • Synthetic Growth Defect: 3
  • Synthetic Lethality: 2
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 425
Molecular Weight (Da) 46,983
Isoelectric Point (pI) 6.19
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVII:800546 to 801823 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1278 800546..801823 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003388
References cited on this page View Complete Literature Guide for PTI1
1) Dichtl B, et al.  (2002) A role for SSU72 in balancing RNA polymerase II transcription elongation and termination. Mol Cell 10(5):1139-50
2) Skaar DA and Greenleaf AL  (2002) The RNA polymerase II CTD kinase CTDK-I affects pre-mRNA 3' cleavage/polyadenylation through the processing component Pti1p. Mol Cell 10(6):1429-39
3) Dheur S, et al.  (2003) Pti1p and Ref2p found in association with the mRNA 3' end formation complex direct snoRNA maturation. EMBO J 22(11):2831-40
4) Ghosh Dastidar R, et al.  (2012) The nuclear localization of SWI/SNF proteins is subjected to oxygen regulation. Cell Biosci 2(1):30