Standard Name	PTC6 1
Systematic Name	YCR079W
Alias	AUP1 2 , PPP2 3
Feature Type	ORF, Verified
Description	Mitochondrial type 2C protein phosphatase (PP2C) with similarity to mammalian PP1Ks; involved in mitophagy; null mutant is sensitive to rapamycin and has decreased phosphorylation of the Pda1 subunit of pyruvate dehydrogenase (1, 2, 3, 4, 5)
Name Description	Phosphatase Two C 1

Chromosomal Location	ChrIII:252845 to 254173 | ORF Map | GBrowse

	View Computational GO annotations for PTC6
Molecular Function
Manually curated	protein serine/threonine phosphatase activity (IDA)
Biological Process
Manually curated	macroautophagy (IGI) mitochondrion degradation (IMP) positive regulation of catalytic activity (IMP) protein dephosphorylation (IMP)
Cellular Component
Manually curated	mitochondrial intermembrane space (IDA) mitochondrial matrix (IDA)
High-throughput	mitochondrion (IDA)

Classical genetics
null	glycogen accumulation: increased cold sensitivity: increased growth in exponential phase: decreased rate heat sensitivity: increased mitophagy: absent pyruvate dehydrogenase complex activity: absent aconitase accumulation: decreased Pda1p subunit of pyruvate dehydrogenase complex modification: increased resistance to caffeine: decreased resistance to sirolimus: decreased survival rate in stationary phase: decreased viability: decreased viable
unspecified	transposable element transposition: decreased
Large-scale survey
null	polyphosphate accumulation: abnormal glycogen accumulation: increased competitive fitness: increased dessication resistance: decreased haploinsufficient heat sensitivity: increased resistance to wortmannin: increased resistance to sirolimus: decreased resistance to ethanol: decreased resistance to acetic acid: decreased resistance to BPS: decreased toxin resistance: decreased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	74 total interaction(s) for 67 unique genes/features.
Physical Interactions	Affinity Capture-MS: 26 Affinity Capture-RNA: 1 Biochemical Activity: 2
Genetic Interactions	Dosage Growth Defect: 1 Negative Genetic: 30 Positive Genetic: 11 Synthetic Growth Defect: 1 Synthetic Lethality: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIII:252845 to 254173 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 2000-09-13
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1329 252845..254173 2011-02-03 2000-09-13
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002133