PTC6/YCR079W Summary Help

Standard Name PTC6 1
Systematic Name YCR079W
Alias AUP1 2 , PPP2 3
Feature Type ORF, Verified
Description Mitochondrial type 2C protein phosphatase (PP2C); has similarity to mammalian PP1Ks; involved in mitophagy; null mutant is sensitive to rapamycin and has decreased phosphorylation of the Pda1 subunit of pyruvate dehydrogenase (1, 2, 3, 4, 5)
Name Description Phosphatase Two C 1
Chromosomal Location
ChrIII:252845 to 254173 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All PTC6 GO evidence and references
  View Computational GO annotations for PTC6
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 7 genes
Resources
Classical genetics
null
unspecified
Large-scale survey
null
Resources
85 total interaction(s) for 72 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 26
  • Affinity Capture-RNA: 1
  • Biochemical Activity: 2

Genetic Interactions
  • Dosage Growth Defect: 1
  • Negative Genetic: 30
  • Phenotypic Enhancement: 1
  • Positive Genetic: 11
  • Synthetic Growth Defect: 8
  • Synthetic Lethality: 2
  • Synthetic Rescue: 3

Resources
Expression Summary
histogram
Resources
Length (a.a.) 442
Molecular Weight (Da) 49,420
Isoelectric Point (pI) 7
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIII:252845 to 254173 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 2000-09-13
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1329 252845..254173 2011-02-03 2000-09-13
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002133
References cited on this page View Complete Literature Guide for PTC6
1) Ruan H, et al.  (2007) The YCR079w gene confers a rapamycin-resistant function and encodes the sixth type 2C protein phosphatase in Saccharomyces cerevisiae. FEMS Yeast Res 7(2):209-15
2) Tal R, et al.  (2007) Aup1p, a yeast mitochondrial protein phosphatase homolog, is required for efficient stationary phase mitophagy and cell survival. J Biol Chem 282(8):5617-24
3) Gey U, et al.  (2008) Yeast pyruvate dehydrogenase complex is regulated by a concerted activity of two kinases and two phosphatases. J Biol Chem 283(15):9759-67
4) Tomaska L  (2000) Mitochondrial protein phosphorylation: lessons from yeasts. Gene 255(1):59-64
5) Sakumoto N, et al.  (2002) A series of double disruptants for protein phosphatase genes in Saccharomyces cerevisiae and their phenotypic analysis. Yeast 19(7):587-99