PSK2/YOL045W Summary Help

Standard Name PSK2 1
Systematic Name YOL045W
Feature Type ORF, Verified
Description PAS-domain containing serine/threonine protein kinase; regulates sugar flux and translation in response to an unknown metabolite by phosphorylating Ugp1p and Gsy2p (sugar flux) and Caf20p, Tif11p and Sro9p (translation); PSK2 has a paralog, PSK1, that arose from the whole genome duplication (1, 2, 3)
Name Description Pas domain-containing Serine/threonine protein Kinase 1
Chromosomal Location
ChrXV:243497 to 246802 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All PSK2 GO evidence and references
  View Computational GO annotations for PSK2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Regulators 3 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
198 total interaction(s) for 124 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 8
  • Affinity Capture-RNA: 1
  • Biochemical Activity: 4
  • Reconstituted Complex: 20

Genetic Interactions
  • Dosage Growth Defect: 4
  • Dosage Rescue: 14
  • Negative Genetic: 131
  • Phenotypic Enhancement: 2
  • Positive Genetic: 7
  • Synthetic Growth Defect: 6
  • Synthetic Lethality: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 1,101
Molecular Weight (Da) 124,371
Isoelectric Point (pI) 5.57
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXV:243497 to 246802 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..3306 243497..246802 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005405
References cited on this page View Complete Literature Guide for PSK2
1) Rutter J, et al.  (2002) Coordinate regulation of sugar flux and translation by PAS kinase. Cell 111(1):17-28
2) Rutter J  (2002) Essay: Amersham Biosciences and Science Prize. PAS domains and metabolic status signaling. Science 298(5598):1567-8
3) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61