PRY2/YKR013W Summary Help

Standard Name PRY2 1
Systematic Name YKR013W
Alias YFW12 2
Feature Type ORF, Verified
Description Sterol binding protein involved in the export of acetylated sterols; secreted glycoprotein and member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); sterol export function is redundant with that of PRY1; may be involved in detoxification of hydrophobic compounds; PRY2 has a paralog, PRY1, that arose from the whole genome duplication (3, 4)
Name Description Pathogen Related in Yeast 1
Chromosomal Location
ChrXI:463959 to 464948 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All PRY2 GO evidence and references
  View Computational GO annotations for PRY2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 13 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
11 total interaction(s) for 11 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 3
  • Co-purification: 1

Genetic Interactions
  • Negative Genetic: 3
  • Phenotypic Enhancement: 1
  • Positive Genetic: 2
  • Synthetic Growth Defect: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 329
Molecular Weight (Da) 33,779
Isoelectric Point (pI) 4.31
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXI:463959 to 464948 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..990 463959..464948 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001721
References cited on this page View Complete Literature Guide for PRY2
1) Ku, T. et al.  (1996) Characterization of the PRY Genes: Yeast homologs of the plant PR-1 proteins. Unpublished
2) Wei YF, et al.  (1995) Suppression of Escherichia coli alkB mutants by Saccharomyces cerevisiae genes. J Bacteriol 177(17):5009-15
3) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
4) Choudhary V and Schneiter R  (2012) Pathogen-Related Yeast (PRY) proteins and members of the CAP superfamily are secreted sterol-binding proteins. Proc Natl Acad Sci U S A 109(42):16882-7