Standard Name	PRX1 1
Systematic Name	YBL064C
Feature Type	ORF, Verified
Description	Mitochondrial peroxiredoxin with thioredoxin peroxidase activity; has a role in reduction of hydroperoxides; reactivation requires Trr2p and glutathione; induced during respiratory growth and oxidative stress; phosphorylated; protein abundance increases in response to DNA replication stress (1, 2, 3, 4, 5)
Name Description	PeroxiRedoXin 1

Chromosomal Location	ChrII:101156 to 100371 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for PRX1
Molecular Function
Manually curated	thioredoxin peroxidase activity (IDA, IMP, ISS)
Biological Process
Manually curated	cell redox homeostasis (IDA, IMP) cellular response to oxidative stress (IGI) response to cadmium ion (IMP)
Cellular Component
Manually curated	mitochondrion (IDA, ISS)
High-throughput	mitochondrion (IDA)

Classical genetics
null	peroxynitrite accumulation: increased glutathione disulfide accumulation: increased metal resistance: decreased metal resistance: normal oxidative stress resistance: decreased replicative lifespan: decreased thermotolerance: decreased
overexpression	metal resistance: increased oxidative stress resistance: increased
Large-scale survey
null	competitive fitness: increased haploinsufficient resistance to arsenite(3-): decreased resistance to cycloheximide: decreased resistance to benzo[a]pyrene: decreased resistance to streptomycin: decreased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	55 total interaction(s) for 48 unique genes/features.
Physical Interactions	Affinity Capture-MS: 11 Affinity Capture-RNA: 3 Affinity Capture-Western: 1 Biochemical Activity: 6 Reconstituted Complex: 2
Genetic Interactions	Negative Genetic: 20 Phenotypic Enhancement: 2 Phenotypic Suppression: 2 Positive Genetic: 1 Synthetic Growth Defect: 7
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrII:101156 to 100371 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..786 101156..100371 2011-02-03 1997-01-28
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000160